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- Case Report
- A case of thanatophoric dysplasia type I with an R248C mutation in the
FGFR3 gene - Eun Jung Noe, Han Wook Yoo, Kwang Nam Kim, So Yeon Lee
- Clin Exp Pediatr. 2010;53(12):1022-1025. Published online December 31, 2010
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Thanatophoric dysplasia (TD) is a short-limb neonatal dwarfism syndrome that is usually lethal in the perinatal period. It is characterized by shortening of the limbs, severely small thorax, large head with a prominent forehead, macrocephaly, curved femur, and flattened vertebral bodies. These malformations result from the mutation in fibroblast growth factor receptor 3 (FGFR-3) gene which is located on the...
- Original Article
- Prevalence and risk factors of the metabolic syndrome in young adults with childhood-onset hypopituitary growth hormone deficiency
- Han Hyuk Lim, Min Jae Kang, In Suk Yun, Young Ah Lee, Choong Ho Shin, Sei Won Yang
- Clin Exp Pediatr. 2010;53(10):892-897. Published online October 31, 2010
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Purpose This study evaluated the prevalence of the metabolic syndrome (MetS) and risk factors for metabolic derangement in young adults with childhood-onset hypopituitary growth hormone deficiency (ACOHGHD).
Methods Thirty patients with ACOHGHD who were treated with hormone-replacement therapy, aged 18 to 29 years, who visited the Seoul National University Children's Hospital between September 2009 and February 2010 were enrolled. Height, weight, waist circumference,...
- Effects of human growth hormone on gonadotropin-releasing hormone neurons in mice
- Janardhan P. Bhattarai, Shin Hye Kim, Seong Kyu Han, Mi Jung Park
- Clin Exp Pediatr. 2010;53(9):845-851. Published online September 13, 2010
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Purpose Recombinant human growth hormone (rhGH) has been widely used to treat short stature. However, there are some concerns that growth hormone treatment may induce skeletal maturation and early onset of puberty. In this study, we investigated whether rhGH can directly affect the neuronal activities of of gonadotropin-releasing hormone (GnRH).
Methods We performed brain slice gramicidin-perforated current clamp recording to examine the direct...
- Case Report
- A case of Pfeiffer syndrome with c833_834GC>TG (Cys278Leu) mutation in the
FGFR2 gene - Min Young Lee, Ga Won Jeon, Ji Mi Jung, Jong Beom Sin
- Clin Exp Pediatr. 2010;53(7):774-777. Published online July 31, 2010
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Pfeiffer syndrome is a rare autosomal dominant disorder characterized by coronal craniosynostosis, brachycephaly, mid-facial hypoplasia, and broad and deviated thumbs and great toes. Pfeiffer syndrome occurs in approximately 1:100,000 live births. Clinical manifestations and molecular genetic testing are important to confirm the diagnosis. Mutations of the fibroblast growth factor receptor 1 (
FGFR1 ) gene orFGFR2 gene can cause Pfeiffer syndrome....
- Original Article
- An 18-year experience of tracheoesophageal fistula and esophageal atresia
- Juhee Seo, Do Yeon Kim, Ai Rhan Kim, Dae Yeon Kim, Seong Chul Kim, In Koo Kim, Ki Soo Kim, Chong Hyun Yoon, Soo Young Pi
- Clin Exp Pediatr. 2010;53(6):705-710. Published online June 23, 2010
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Purpose To determine the clinical manifestations and outcomes of patients with tracheoesophageal fistula (TEF) and esophageal atresia (EA) born at a single neonatal intensive care unit.
Methods A retrospective analysis was conducted for 97 patients with confirmed TEF and EA who were admitted to the neonatal intensive care unit between 1990 and 2007.
Results The rate of prenatal diagnosis was 12%. The average gestational age...
- Final height of patients with congenital heart disease
- Soon Ju Lee, Young Kuk Cho, Jae Sook Ma
- Clin Exp Pediatr. 2010;53(2):203-209. Published online February 15, 2010
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Purpose : Growth impairment is usually observed in children with congenital heart disease (CHD). Studies on the final height and weight of this population are insufficient. Our aim was to evaluate the final height of children with CHD and to identify the relationship between CHD and growth. Methods : We recorded the values of final height and weights of 105 CHD... -
- Case Report
- Perianastomotic ulceration presenting with long-term iron deficiency anemia and growth failure: A case report and review of the literature
- Kyung Ji Kang, Eun Ha Kim, Eun Young Jung, Woo-Hyun Park, Yu-Na Kang, Ae Suk Kim, Jin-Bok Hwang
- Clin Exp Pediatr. 2010;53(1):89-92. Published online January 15, 2010
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Perianastomotic ulceration (PAU) rarely occurs after small bowel resection in infancy. Since the understanding of its pathogenesis is incomplete, an effective method of treatment has not yet been discovered. We report the first case in Korea of a 10-year-old girl with chronic iron deficiency anemia (IDA) and growth failure who was diagnosed with PAU at colonoscopy. Seven years were required... -
- Original Article
- Effect of GnRH analogue on the bone mineral density of precocious or early pubertal girls
- Jeong Sook Lim, Heon-Seok Han
- Clin Exp Pediatr. 2009;52(12):1370-1376. Published online December 15, 2009
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Purpose : Treatment of precocity with gonadotropin releasing hormone analogue (GnRHa) might theoretically exert a detrimental effect on the bone mass during pubertal development. We investigated the short-term changes in bone mineral density (BMD) during GnRHa treatment and the enhancement in the changes with the co-administration of GnRHa and human growth hormone (hGH). Methods : Forty girls with precocious or... -
- Economic evaluation of a weekly administration of a sustained-release injection of recombinant human growth hormone for the treatment of children with growth hormone deficiency
- Hye-Young Kang, Duk Hee Kim, Sei-Won Yang, Yoon-Nam Kim, Miseon Kim
- Clin Exp Pediatr. 2009;52(11):1249-1259. Published online November 15, 2009
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Purpose : From a societal perspective, we evaluated the cost-effectiveness of a novel sustained-release injection of recombinant human growth hormone (GH) administered on a weekly basis compared with that of the present daily GH injection for the treatment of children with GH deficiency. Methods : Health-related utility for GH therapy was measured based on the visual analogue scale. During July... -
- Review Article
- Treatment of chronic kidney disease in children
- Joo Hoon Lee
- Clin Exp Pediatr. 2009;52(10):1061-1068. Published online October 15, 2009
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The treatment of pediatric patients with chronic renal disease comprises management of nutritional imbalance, fluid, electrolyte, and acid-base disturbances, mineral bone disease, anemia, hypertension, and growth retardation. The treatment also includes administration of appropriate renal replacement therapy, if required. Adequate dietary intake of carbohydrates, fats, and proteins and caloric intake must be encouraged in such patients to ensure proper growth... -
- Original Article
- Catch up growth in children born small for gestational age by corrected growth curve
- Myung Ki Jung, Ji Eun Song, Seung Yang, Il Tae Hwang, Hae Ran Lee
- Clin Exp Pediatr. 2009;52(9):984-990. Published online September 15, 2009
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Purpose:Being small for gestational age (SGA) is a risk factor of short stature in children. Genetic background such as mid-parental height (MPH) is known to influence growth of children born SGA. We studied the relationship between growth of children born SGA and MPH and studied the effects of insulin-like growth factor (IGF-I) and insulin-like growth factor binding protein 3 (IGFBP-3)... -
- Effect of angiotensin II inhibition on the epithelial to mesenchymal transition in developing rat kidney
- Hyung Eun Yim, Kee Hwan Yoo, In Sun Bae, Young Sook Hong, Joo Won Lee
- Clin Exp Pediatr. 2009;52(8):944-952. Published online August 15, 2009
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Purpose:To investigate the effects of angiotensin II inhibition on the epithelial to mesenchymal transition (EMT) in the developing kidney, we tested the expression of EMT markers and nestin in angiotensin converting enzyme (ACE) inhibitor-treated kidneys. Methods:Newborn rat pups were treated with enalapril (30 mg/kg/d) or a vehicle for 7 days. Immunohistochemistry for the expression of α-smooth muscle actin (SMA), E-cadherin, vimentin, and nestin were... -
- Growth responses to growth hormone therapy in children with attenuated growth who showed normal growth hormone response to stimulation tests
- Jae Hyun Kim, Hey Rim Chung, Young Ah Lee, Sun Hee Lee, Ji Hyub Kim, Choong Ho Shin, Sei Won Yang
- Clin Exp Pediatr. 2009;52(8):922-929. Published online August 15, 2009
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Purpose:The aim was to investigate the clinical characteristics and responses to growth hormone (GH) therapy in children with attenuated growth who showed normal GH responses to GH stimulation tests (GHST). Methods:The study included 39 patients with height velocity (HV) of less than 4 cm/yr and normal GHST results. Clinical characteristics of patients were analyzed retrospectively. Results:Eleven were born as small for gestational age (SGA)... -
- Expression of nitric oxide synthase isoforms and N-methyl-D-aspartate receptor subunits according to transforming growth factor-β1 administration after hypoxic-ischemic brain injury in neonatal rats
- Hae Young Go, Eok Su Seo, Woo Taek Kim
- Clin Exp Pediatr. 2009;52(5):594-602. Published online May 15, 2009
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Purpose : Transforming growth factor (TGF)-β1 reportedly increases neuronal survival by inhibiting the induction of inducible nitric oxide synthase (NOS) in astrocytes and protecting neurons after excitotoxic injury. However, the neuroprotective mechanism of TGF-β1 on hypoxic-ischemic (HI) brain injury in neonatal rats is not clear. The aim of this study was to determine whether TGF-β1 has neuroprotective effects via a... -
- Effect of growth hormone on neuronal death in hippocampal slice cultures of neonatal rats exposed to oxygen-glucose deprivation
- Kyung Sik Hong, Jihui Kang, Myeung Ju Kim, Jeesuk Yu, Young Pyo Chang
- Clin Exp Pediatr. 2009;52(5):588-593. Published online May 15, 2009
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Purpose : To investigate whether growth hormone (GH) has a protective effect on neurons in hippocampal slice cultures of neonatal rats exposed to oxygen-glucose deprivation (OGD). Methods : Cultured hippocampal slices of 7-day-old rats were exposed to OGD for 60 min. Then, the slices were immediately treated with three doses of GH (5, 50, or 500 µM) in media. The... -
- Questionnaire-based analysis of growth-promoting attempts among children visiting a university growth clinic
- Kyoung Huh, Mi Jung Park
- Clin Exp Pediatr. 2009;52(5):576-580. Published online May 15, 2009
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Purpose : Growth-promoting attempts are widespread in Korea, but little is known about their prevalence or associated factors. This study was designed to assess the prevalence of growth-promoting attempts among children visiting a university growth clinic. Methods : A questionnaire-based survey was carried out with 823 children (416 boys, 407 girls) who visited the growth clinic at Paik Hospital. Results... -
- Analysis of cytosine adenine repeat polymorphism of the IGF-I promoter gene in children with idiopathic short stature
- Jae Hoon Moon, Woo Yeong Chun
- Clin Exp Pediatr. 2009;52(3):356-363. Published online March 15, 2009
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Purpose : A polymorphism in the IGF-I gene promoter region is known to be associated with serum IGF-I levels, birth weight, and body length, suggesting that IGF-I gene polymorphism might influence postnatal growth. The present study aimed to investigate the role of this polymorphic cytosine-adenine (CA) repeat of the IGF-I gene in children with idiopathic short stature. Methods : The... -
- Case Report
- A case of mosaic ring chromosome 13 syndrome
- Soo Young Kim, Soo Min O, Mi Jeong Kim, Eun Song Song, Young Ok Kim, Young Youn Choi, Young Jong Woo, Tai Ju Hwang
- Clin Exp Pediatr. 2009;52(2):242-246. Published online February 15, 2009
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The clinical features of ring chromosome 13 include mental and growth retardation, CNS anomalies, facial dysmorphism, cardiac defects, genital malformations, limb anomalies, skeletal deformities and anal malformations. Although many cases of ring chromosome 13 have been reported worldwide, only 6 cases have been reported in Korea, and the latter cases were not mosaic but pure ring chromosome 13. Here we... -
- Original Article
- Factors for persistent growth hormone deficiency in young adults with childhood onset growth hormone deficiency
- Young Ah Lee, Hye Rim Chung, Se Min Lee, Jae Hyun Kim, Ji Hyun Kim, Sun Hee Lee, Choong Ho Shin, Sei Won Yang
- Clin Exp Pediatr. 2009;52(2):227-233. Published online February 15, 2009
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Purpose : Growth hormone (GH) replacement after retesting is necessary because impairment of body composition and cardiovascular health has been more severe in adult patients with persistent GH deficiency (GHD) from childhood to adulthood. This study aimed to investigate the factors for persistent GHD and define a highly probable group of persistent GHD in young adults with childhood-onset GHD. Methods :... -
- Review Article
- Growth and sex differentiation of children born small for gestational age
- Se Young Kim
- Clin Exp Pediatr. 2009;52(2):142-151. Published online February 15, 2009
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The incidence of small for gestational age (SGA) births is frequent, accounting for 2.3% to 8% of all live births. Several childhood and adult diseases are related to early postnatal growth and birth size, and 10% of children born SGA may have a short stature throughout postnatal life. Additionally, they may have abnormal growth hormone (GH)-insulin like growth factor axis,... -
- Original Article
- Effects of soy-based formula on infants` growth and blood laboratory values spanning 3 years after birth
- Ji Eun Yoon, Mi-Jung Kim, Heon-Seok Han
- Clin Exp Pediatr. 2009;52(1):28-35. Published online January 15, 2009
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Purpose : We compared body growth, blood cell counts, and chemistry among infants receiving soy-based formula (SF), breast milk (BM), and casein-based formula (CF). Methods : Full-term neonates delivered at our hospital from June 2001 to August 2003 were recruited and divided into 3 feeding groups (BM=20, SF=19, CF=12) according to the parents wishes. Breast feeding or artificial formulae were... -
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- Study on the diagnostic utility of serum levels of insulin-like growth Factor-I and insulin-like growth factor binding protein-3 in growth hormone deficiency
- Geun Ha Chi, Jeong Nyeo Lee, Woo Yeong Chung
- Clin Exp Pediatr. 2008;51(12):1329-1335. Published online December 15, 2008
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Purpose : This study aimed to determine the best cutoff line for insulin-like growth factor (IGF)-I and insulin-like growth factor binding protein (IGFBP)-3 to discriminate between growth hormone deficiency (GHD) patients and the control group. Methods : Two hundred thirty subjects with normal controls (129 boys and 101 girls, aged 7-15 years), 14 patients with complete GHD (12 boys and... -
- Prevalence and trends in obesity among Korean children and adolescents in 1997 and 2005
- Kyungwon Oh, Myoung Jin Jang, Na Yeoun Lee, Jin Soo Moon, Chong Guk Lee, Myung Hwan Yoo, Young Taek Kim
- Clin Exp Pediatr. 2008;51(9):950-955. Published online September 15, 2008
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Purpose : The objective of this study was to provide current estimates of the prevalence and examine trends of overweight and obesity in children and adolescents. Methods : Height and weight measurements from 183,159 (112,974 in 1997, 70,185 in 2005) children and adolescents aged 2 to 18 years were obtained via the 1997 and 2005 National Growth Survey. Obesity among... -
- Transforming growth factor-β promoted vascular endothelial growth factor release by human lung fibroblasts
- Sang Uk Park, Joo Hwa Shin, Jae Won Shim, Deok Soo Kim, Hye Lim Jung, Moon Soo Park, Jung Yeon Shim
- Clin Exp Pediatr. 2008;51(8):879-885. Published online August 15, 2008
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Purpose : The human lung fibroblast may act as an immunomodulatory cell by providing pro-inflammatory cytokines and chemokines, which are important in airway remodeling. Vascular endothelial growth factor (VEGF) induces mucosal edema and angiogenesis. Thymus and activation regulated chemokine (TARC) induces selective migration of T helper 2 cells. We investigated whether human lung fibroblasts produced VEGF and TARC, and the... -
- Effects and adverse-effects of growth hormone therapy in children with Prader-Willi syndrome: A two year study
- Su Jin Kim, Joong Bum Cho, Min Jung Kwak, Eun Kyung Kwon, Kyung Hoon Paik, Dong-Kyu Jin
- Clin Exp Pediatr. 2008;51(7):742-746. Published online July 15, 2008
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Purpose : The objective of this study was to evaluate the effects and adverse side-effects of growth hormone (GH) therapy in children with Prader-Willi syndrome (PWS). Methods : Forty-one patients who had been treated with GH for more than two years (24 boys and 17 girls, mean age 7.3?.3 years during treatment initiation) were enrolled for this study. Results : After... -
- The relationship between adiponectin, leptin, insulin, insulin-like growth factor and IGF binding protein-3 in cord blood and neonatal anthropometric parameters
- Hai Jung Cho, Ji Young Kim, Me Jin Kim, Il Tae Hwang, Hae Ran Lee
- Clin Exp Pediatr. 2008;51(7):722-728. Published online July 15, 2008
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Purpose : This study was designed to examine the effects of adiponectin, leptin, insulin, insulin-like growth factor (IGF)-I and IGF binding protein (BP)-3 levels in cord blood on weight, length, and adiposity at birth in healthy term infants. In addition, we evaluated the mechanism to change the hormone levels in appropriate for gestational age (AGA) during the first month. Methods :... -
- Increased vascular endothelial growth factor in children with acute Mycoplasma pneumoniae pneumonia and wheezing
- Young Seo, Byung Keun Yu, Yeon Joung Oh, Yoon Lee, Young Yoo, Ji Tae Choung, Young Yull Koh
- Clin Exp Pediatr. 2008;51(5):487-491. Published online May 15, 2008
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Purpose : Although Mycoplasma pneumoniae (M. pneumoniae) infection can cause wheezing in non-asthmatic children, the mechanisms of this symptom remain unclear. Vascular endothelial growth factor (VEGF) is a major mediator of angiogenesis and vascular permeability, and is also known to be elevated in cases of chronic pulmonary disease such as asthma. We hypothesized that VEGF may increase in children with... -
- Phenotype-genotype correlations and the efficacy of growth hormone treatment in Korean children with Prader-Willi syndrome
- Keun Wook Bae, Jung Min Ko, Han-Wook Yoo
- Clin Exp Pediatr. 2008;51(3):315-322. Published online March 15, 2008
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Purpose : Prader-Willi syndrome (PWS) is a complex genetic disorder, caused by the deletion of the paternally derived 15q11-13 region or the maternal uniparental disomy of chromosome 15 (mUPD(15)). In this study, we compared phenotypic differences between those patients whose disease was caused by microdeletion and those caused by mUPD(15). In addition, a comparison of the efficacy of growth hormone... -
- Serum levels of free insulin-like growth factor-I and clinical value in healthy children
- Young Hee Chung, Woo Yeong Chung
- Clin Exp Pediatr. 2008;51(1):47-53. Published online January 15, 2008
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Purpose : The serum levels of total insulin-like growth factor (IGF)-I and IGF binding protein (IGFBP)- 3 reflect endogenous growth hormone (GH) secretion in healthy children. Free form of IGF-I which is suggested to have more potent biological action than complex form of IGF-I. The aim of this study is to investigate the serum levels of free IGF-I and its... -
- Review Article
- The methodology for developing the 2007 Korean growth charts and blood pressure nomogram in Korean children and adolescents
- Soon Young Lee, Youn Nam Kim, Yeon Ji Kang, Myoung-Jin Jang, Jinheum Kim, Jin Soo Moon, Chong Guk Lee, Kyungwon Oh, Young Taek Kim, Chung Mo Nam
- Clin Exp Pediatr. 2008;51(1):26-32. Published online January 15, 2008
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Purpose : This study was to provide the methods of developing the growth charts and the blood pressure nomogram among Korean children and adolescents. Methods : The growth charts were developed based on the data from the national growth surveys for children and adolescents in 1998 and 2005. The percentile charts were developed through two stages. At the first stage, the... -
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Impact Factor3.2
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8.02023CiteScore94nd percentilePowered by
