Question: When is the best screening timing and what is the risk factor for developmental dysplasia of the hip (DDH) in preterm infants? Finding: Ultrasonography performed earlier than 38 weeks of postmenstrual age caused unnecessary subsequent ultrasonography. DDH did not occur predominantly on the left side or in breech infants. Meaning: The screening timing, etiology, and risk factors for DDH in preterm infants are somewhat different from those in term infants. |
Fungal infections are rarely responsible for arthritis. Few cases of fungal arthritis have been reported, even in immunocompromised hosts susceptible to low-virulence organisms. Herein, the authors report the first case of |
Reactive arthritis comprises a subgroup within infection-associated arthritides in genetically susceptible hosts. Researchers and clinicians recognize two clinical forms of reactive arthritis which occurs after genitourinary tract infection and after gastrointestinal tract infection. Chlamydia infection has been implicated as the most common agent associated with post-venereal reactive arthritis. Studies have proposed Shigella infection, |
The systematic approach to pharmacologic treatment is typically to begin with the safest, simplest, and most conservative measures. It has been realized that the more rapidly inflammation is under control, the less likely it is that there will be permanent sequelae. Nonsteroidal anti-inflammatory drugs (NSAIDs) are the mainstay of initial treatment for inflammation. In addition, the slow-acting antirheumatic drugs (SAARDs)... |
Juvenile idiopathic arthritis (JIA) is comprised of a heterogeneous group of several disease subtypes that are characterized by the onset of arthritis before the age of 16 years and has symptoms lasting at least 6 weeks. The previous classification of JIA included seven different categories, whereas its current classification was compiled by the International League of the Association for Rheumatology,... |
Juvenile rheumatoid arthritis (JRA) is the most common rheumatic childhood disease; its onset is before 16 years of age and it persists for at least 6 weeks. JRA encompasses a heterogeneous group of diseases that is classified according to 3 major presentations: oligoarthritis, polyarthritis, and systemic onset diseases. These presentations may originate from the same or different causes that involve... |
Tumor necrosis factor-α (TNF-α) is a major proinflammatory cytokine involved in the pathophysiology of juvenile rheumatoid arthritis. Etanercept is an effective inhibitor of TNF-α and has shown a beneficial effect in patients with JRA. However, the most important cause of concern related to etanercept administration is infection. We report a case of encephalitis in a JRA patient receiving long-term treatment... |
The diagnosis of juvenile rheumatoid arthritis (JRA) is based on patient's age at disease onset, symptom duration, gender, and clinical manifestations. JRA is of unknown origin, begins under the age of 16, and persists for a minimum of 6 weeks. JRA is categorized into three principal types, systemic, oligoarticular and polyarticular. Infection, other connective tissue diseases, malignancy, trauma, and immunodeficiency... |
Purpose : Juvenile rheumatoid arthritis(JRA) is one of the most common rheumatic diseases of childhood and is an important cause of short- and long-term disability. The purpose of this study was to determine the disease course and outcome in childhood patients with JRA. Methods : Fifty nine patients with JRA who were diagnosed and treated in the Department of Pediatrics, Asan... |
Purpose : Septic arthritis is uncommon in neonates, and the diagnosis of septic arthritis in newborns is difficult because of non-specific laboratory findings and paucity of signs and symptoms. When appropriate treatment is delayed, permanant sequelae are inevitable. We report a retrospective study of 22 neonates who were diagnosed with septic arthritis. Methods : We reviewed 22 patients, who were diagnosed... |
Objective : Besides the functions of histones in the nucleus of the cells, there is growing evidence that histones have many other extra-cellular or extra-nuclear functions, such as stabilizing axonemal microtubule of sea urchin sperm flagella. This microtule assembly function of the histone is similar to that of taxol, which has an effect of controlling joint inflammation. In this study,... |
Purpose : In this study, a possible suppressive effect of a flavon extracted from Artemisia absinthium on a mouse collagen-induced arthritis (CIA) model was investigated. Methods : DBA/1 mice were injected intradermally with emulsified chicken type II collagen. Three weeks after immunization, a flavon was introduced p.o. everyday. Clinical incidences of arthritis and arthritis index were measured. Measurement of anti-collagen antibodies... |
In Kawasaki disease, arthritis may occur, generally affecting the hands, knees, ankles, or hips. Operations have not usually been needed. We report a case of Kawasaki Disease with multiple septic arthritis which was caused by S. pneumoniae and which needed athrotomy with drainage for both hips, both knees, and both ankle joints. A two year, ten-month-old girl was admitted to... |
We evaluated the clinical and laboratory characteristics of five children with Kawasaki disease who had showed arthritis after responding to intravenous immunoglobulin(IVIG) treatment. Age distribution was between 13 months and six years of age(mean 3.2?.6 years). There were two males and three females. Arthritis occurred when acute symptoms were subsiding, with the average onset on day 5.8?.8 after final IVIG... |
Purpose : Though acute pyogenic infections of musculoskeletal system are infrequent in children, delayed diagnosis or inadequate management may cause serious chronic sequelae. We analysed 40 cases of children who were affected by acute septic osteomyelitis and/or septic arthritis to find etiologic agents and to establish proper initial antimicrobial therapy. Methods : Medical records of 40 cases of microbiologically confirmed acute... |
We report a case of septic arthritis due to H. influenzae associated with atypical Kawasaki disease. A 2-year-old boy was admitted to our orthopedic department due to limping gait of the right leg. CT finding of right hip joint revealed fluid collection. He was diagnosed as transient synovitis and septic arthritis. He was treated with antibiotics, but no incision nor... |
Purpose : It is well known that the Acanthopanax koreanum extract has an anti-inflammatory action without any adverse effects reported. We conducted this study to see whether the Acanthopanax koreanum extract has a preventive effect on the development of collagen induced arthritis in DBA/1J mice. Methods : Three groups of BDA/1J mice were immunized by intradermal injection of 2mg/kg bovine type... |
Disseminated intravascular coagulation(DIC) occurs rarely but can cause death in patients with juvenile rheumatoid arthritis(JRA), especially in the systemic type. The reports of DIC complicating JRA have increased recently. We experienced a 13 - year - old female patient with systemic JRA who died of DIC. The patient had been managed with aspirin, steroid, nonsteroidal anti-inflammatory drug for 7 years,... |
Purpose : Acute septic arthritis in infancy and childhood is uncommon. Delay of diagnosis and inappropriate treatment of septic arthritis results in permanent physical sequelae. We studied the initial treatment, clinical manifestations, involved sites, and etiologic organisms of septic arthritis. Methods : We reviewed 74 patients who were diagnosed septic arthritis in Departments of Pediatrics and Orthopedic Surgery, Yonsei University College of Medicine from July 1986... |
Purpose : The purpose of this study was to analyse clinical and laboratory patterns in patients in Korea with juvenile Rheumatoid Arthritis(JRA), pauciarticular type and to know the characteristics of pauciarticular JRA in Korea. Methods : Twenty-three cases of pauciarticular juvenile rheumatoid arthritis(JRA) who were diagnosed in the department of Pediatrics, Seoul National University hospital (from june 1988 to May 1994)... |
Poststreptococcal reactive arthritis/arthralgia is characterized as an evidence of group A beta hemolytic streptococcal infection and does not fulfill the modified Jones criteria for a diagnosis of acute rheumatic fever. We had used to meet the patients with incomplete acute rheumatic fever who had more than 3 items of minor Jones criteria, or arthralgia or arthritis with one or two... |
Rheumatoid factor is a commonly used laboratory test by clinicians to assess the children with possible juvenile rheumatoid arthritis. To assess its diagnositc value and clinical significance we reviewed the case histories of the patients in whom latex agglutinating rheumatoid factor was tested during November 1988 to April 1991 at Seoul National University Children's Hospital. There were 61 patients with... |
The authors analyzed the clinical features, and the therapeutic responses in 29 patients with juvenile rheumatoid arthritis who were diagnosed and followed at Department of Pediatrics, Pusan National University Hospital from 1980. 1 to 1990. 6. The following results were obtained 1) Of the total 29 patients, 12cases (41.4%) were pauciarticular type II and 7cases (24.2%) were polyarticular RF(—) type. Seventeen cases (58.7%) were 8-11 yrs... |
Acute pyogenic arthritis of hip is a serious infection that can lead to truly devastating complica- tions especially in neonatal period and infancy. Clinical survey on twelve neonates and infants (14 hip joints) with acute pyogenic arthritis of hip who were admitted to the Departments of Pediatrics and Orthopedic Surgery, Seoul National University Hospital from Jan. 1980 to Dec. 1989 were done. The results... |
We recently experienced a case of systemic-onset juvenile rheumatoid arthritis with protracted and variable clinical course with multiple complications and sequeles including pericarditis, disseminated intravascular coagulation, severe ankylosis and bony fusion of neural arches of C2 through C6 vertebrae, and multiple chronic arthritis causing joint deformities at relatively young age of nine. A brief review of related literatures is also presented. |
A clinical observation on 70 patients of juvenile rheumatoid arthritis who were admitted to S.N.U.H. during the 6 year period from Jan. 1979 to Dec. 1984, was assessed. The results were as follows; 1) On type classification, systemic type(37.2%) was most frequent, followed by RF negative polyarticular type, pauciarticular type H, RF positive polyarticular type and pauciarticular type I in order of frequency. The... |