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"Most viewed" Articles are from the articles published in 2022 during the last six month.
- Editorial
- Neurology
- Lumbar puncture or not: when does febrile seizure require a neurodiagnostic evaluation? (640 times)
- Seung Soo Kim
- Clin Exp Pediatr. 2023;66(2):68-69. Published online December 9, 2022
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· A neurodiagnostic evaluation (lumbar puncture, blood tests, electroencephalography, and neuroimaging) is not indicated in most patients with simple febrile seizures.
· A lumbar puncture is indicated when a central nervous system infection is suspected in any patient with febrile seizures.
· Blood tests (glucose, electrolytes, and complete blood count) are indicated in patients with persistent seizure after benzodiazepine treatment, prolonged loss of consciousness, poor general condition, or signs of dehydration.
- Perspective
- Infection
- Statement on healthcare system preparedness in response to COVID-19 Omicron subvariants BA.4 and BA.5 surge in Korea from the Korean Pediatric Society and Korean Society of Pediatric Infectious Diseases (634 times)
- Eun Young Cho, Dong Hyun Kim, Soo-Han Choi, Ki Wook Yun, Jong Gyun Ahn, Hye-Kyung Cho, Hyunju Lee, Jina Lee, Taek-Jin Lee, Byung-Wook Eun, Jin Lee, Dae Sun Jo, Yun-Kyung Kim, Yae-Jean Kim; Committee on Infectious Diseases of the Korean Pediatric Society
- Clin Exp Pediatr. 2022;65(11):510-511. Published online September 23, 2022
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In order to respond to the recent surge in coronavirus disease 2019 (COVID-19) cases and the continuously changing epidemiology of COVID-19, a sustainable and flexible pediatric healthcare system must be prepared considering the specificity of pediatric care. We demand a more proactive response from the health authorities to check the current state of pediatric COVID-19 patient care and to ensure that pediatric patients receive appropriate and timely management.
- Letter to the Editor
- Developmental and Behavioral Medicine
- Efficacy of social skills group intervention among children with mild autism spectrum disorder (628 times)
- Lee Ling Low, Ker Yang Chua, Bih Hwa Ching
- Clin Exp Pediatr. 2024;67(7):368-370. Published online May 31, 2024
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- Retraction Notice
- Coronavirus disease 2019 in a 2-month-old male infant: a case report from Iran (626 times)
- Hosein Heydari, Seyed Kamal Eshagh Hossaini, Ahmad Hormati, Mahboubeh Afifian, Sajjad Ahmadpour
- Clin Exp Pediatr. 2022;65(8):417-417. Published online July 19, 2022
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- Original Article
- Emergency Medicine
- Nonfatal injuries in Korean children and adolescents, 2007–2018 (607 times)
- Gyu Min Yeon, Yoo Rha Hong, Seom Gim Kong
- Clin Exp Pediatr. 2022;65(4):194-200. Published online September 9, 2021
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Question: How many children and adolescents have experienced nonfatal injuries in the previous year?
Finding: Among Korean children and adolescents, 8.1% experienced at least one injury per year. We found no significant change in the incidence of injuries over the previous 12 years.
Meaning: The incidence of injuries is higher than this estimation; therefore, more attention and effort are needed to prevent injuries among children and adolescents.
- Letter to the Editor
- Developmental and Behavioral Medicine
- The influence of parental eating behaviors, child-feeding practices, and infants’ temperaments upon infants’ eating behaviors (606 times)
- Goh Woon Lim, Kyoung Min Shin
- Clin Exp Pediatr. 2022;65(9):466-468. Published online June 27, 2022
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- Original Article
- Developmental and Behavioral Medicine
- Parenting stress and interactive engagement behaviors in children with developmental delay (606 times)
- Jung Sook Yeom, Rock Bum Kim, Jae Young Cho, Ji Sook Park, Eun Sil Park, Ji-Hyun Seo, Jae-Young Lim, Hyang-Ok Woo
- Clin Exp Pediatr. 2023;66(6):252-261. Published online May 19, 2023
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· Question: What level of parenting stress is experienced by parents of children with developmental delays (DDs) without autism spectrum disorder, and what factors contribute to it?
· Findings: Parents of children with DDs experienced high parenting stress that were significantly mediated by their children’s low interactive behaviors.
· Meaning: The interactive behaviors of children with DDs mediate parenting stress.
- Infection
- Predicting COVID-19 transmission in a student population in Seoul, South Korea, 2020–2021 (605 times)
- Young Hwa Lee, Han Ho Kim, Young June Choe
- Clin Exp Pediatr. 2023;66(4):173-178. Published online December 22, 2022
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Question: What is the spatial distribution and determinants of coronavirus disease 2019 (COVID-19) infection among students in Korea?
Finding: The community population was closely associated with the risk of COVID-19, and the number of students per school class were inversely associated with COVID-19 rates in students.
Meaning: Our finding suggests that controlling the community-level burden of COVID-19 can help prevent sudden acute respiratory syndrome coronavirus 2 infection in school-aged children.
- Review Article
- Allergy
- Management of patients with allergic diseases in the era of COVID-19 (568 times)
- Eun Lee
- Clin Exp Pediatr. 2022;65(11):529-535. Published online September 23, 2022
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In the early days of the coronavirus disease 2019 (COVID-19) pandemic, allergic diseases, especially asthma, were considered to be risk factors for severe COVID-19 infection, hospitalization, and death. These concerns stemmed from the idea that individuals with allergic diseases are generally more susceptible to respiratory virus infections, which are major causes of exacerbation of allergic diseases. However, epidemiologic data with...
- Editorial
- Infection
- Impact and role of vitamins as immunonutrition in children during COVID-19 pandemic (567 times)
- Yoo Min Lee
- Clin Exp Pediatr. 2023;66(5):212-214. Published online April 18, 2023
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· Vitamins have effector mechanisms in the innate and adaptive immune systems and potential roles in preventing and reducing the severity of coronavirus disease 2019 (COVID-19).
· Vitamins may be immunonutrients in the treatment of COVID-19 infections and prevention of patient deterioration due to critical illness, thus demonstrating the significance of a nutritious, well-balanced diet.
- Original Article
- Hematology
- Changes and correlations of T-cell coinhibitory molecule programmed death-1 and interferon-γ in pediatric immune thrombocytopenia (563 times)
- Fady Mohamed El-Gendy, Amira M.F. Shehata, Esam Awad Abd El-Kawy, Mahmoud Ahmed El-Hawy
- Clin Exp Pediatr. 2023;66(3):127-133. Published online February 24, 2023
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Question: What are the PD-1+ CD4+ T cells percentages and serum interferon gamma (IFN-γ) levels of pediatric patients with immune thrombocytopenia (ITP)?
Finding: Compared with healthy controls, the PD-1+ CD4+ T cells percentages and IFN-γ levels were significantly higher in ITP patients before and 1 month after therapy.
Meaning: Our findings suggest that PD-1+ CD4+ T cells and IFN-γ are involved in the pathophysiological process of ITP.
- Gastroenterology
- Ability of polymicrobial probiotic and mono-strain probiotic to reduce functional abdominal pain in children: a randomized clinical trial (562 times)
- Seyed Sajad Jafari, Seyed Mojtaba Hashemi, Bahman Sadeghi, Amir Almasi-Hashiani
- Clin Exp Pediatr. 2022;65(12):589-594. Published online October 31, 2022
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· This study compared the ability of 2 probiotics to reduce and improve functional abdominal pain (FAP) in children.
· In the polymicrobial probiotic (PMP) group, 10.34% of children reported no pain; in the mono-strain probiotic (MSP) group, all patients reported low-degree pain. The mean pain score decreased significantly over time in both groups.
· The use of both PMP and MSP is recommended to reduce pain in patients with FAP.
- Editorial
- Nephrology (Genitourinary)
- Optimal hemodialysis treatment for pediatric kidney failure patients (560 times)
- Yo Han Ahn
- Clin Exp Pediatr. 2023;66(3):125-126. Published online February 15, 2023
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· Although the basic concept of hemodialysis (HD) is similar in adults and children, specific factors must be considered in the latter, including the small dialyzer and circuit, difficult vascular access, and frequent complications.
· HD-associated complications include catheter-related problems, hemodynamic instability, and neurodevelopmental and cognitive dysfunction.
· Pediatric HD is challenging, and steady efforts are needed to perform it safely and reduce its complications, thereby improving clinical outcomes.
- Infection
- Importance of maintaining a high childhood vaccination rate and surveillance program against Japanese encephalitis in Korea (533 times)
- Su Eun Park
- Clin Exp Pediatr. 2022;65(3):127-128. Published online February 16, 2022
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∙ Recent epidemiologic changes of Japanese encephalitis (JE) in Korea are area (rural to urban or suburban) and age shift (children to adult).
∙ Although the main factors contributing to recent epidemiologic changes of JE are not well identified, maintaining high vaccination rates of JE appear to be important in preventing of JE in all age groups.
∙ Continuous surveillance for epidemiology and seroprevalence should be carried out.
- Gastroenterology
- Gut microbiota’s impact on obesity (528 times)
- Sujin Jeong
- Clin Exp Pediatr. 2023;66(7):294-295. Published online June 14, 2023
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· An imbalance of the gut microbiota with a relative increase in Firmicutes versus Bacteroidetes is associated with the pathogenesis of obesity.
· Dysbiosis is associated with microbial genes associated with short-chain fatty acids (SCFA) production and increased colonic SCFA levels. SCFAs have also been shown to regulate appetite and satiety hormones, which can affect food intake and energy balance.
· A dietary high-fat intake is reportedly associated with increased plasma lipopolysaccharide. Altered Toll-like receptor-4 signaling leads to propagating the cascade of further inflammation and promoting insulin resistance.
- Nephrology (Genitourinary)
- Clinical considerations and practical issues of kidney complications in children after COVID-19 infection or vaccination (520 times)
- Jiwon Jung, Joo Hoon Lee
- Clin Exp Pediatr. 2024;67(1):35-36. Published online November 17, 2023
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· The proper monitoring for and treatment of coronavirus disease 2019 (COVID-19)-induced acute kidney injury, which is common in critically ill children, are recommended.
· Glomerulopathy associated with COVID-19 or its vaccination has been reported, and the overall clinical course is similar to that of non-COVID-19-associated diseases.
· Additional COVID-19 vaccinations are recommended; however, careful and individualized decisions should be made in patients with COVID-19- or vaccination-associated glomerulopathy.
- Cardiology
- Coronavirus disease 2019 and mRNA vaccines: what’s next – miRNA? (504 times)
- Joon Kee Lee, Heon-Seok Han
- Clin Exp Pediatr. 2022;65(6):302-303. Published online March 28, 2022
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MicroRNAs (miRNAs) are small single-stranded noncoding RNA molecules that function in RNA silencing and the posttranscriptional regulation of gene expression. The potential role of miRNAs as biomarkers of myocarditis is promising, and miRNAs are expected to be utilized in various clinical fields in the future.
- Original Article
- Hematology
- Effect of cyclic pamidronate administration on osteoporosis in children with β-thalassemia major: a single-center study (501 times)
- Mahmoud A. El-Hawy, Nagwan Y. Saleh
- Clin Exp Pediatr. 2022;65(8):405-409. Published online June 7, 2022
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Question: What is the effect of cyclic pamidronate administration on osteoporosis in children with β-thalassemia major?
Finding: The dual-energy x-ray absorptiometry scan findings of children with β-thalassemia major and osteoporosis were improved after pamidronate administration.
Meaning: Cyclic pamidronate effectively treated osteoporosis in children with β-thalassemia major.
- Cardiology
- Early myocardial functional abnormalities in primary dyslipidemia: clinical and echocardiographic observations in young children from a highly consanguineous population (493 times)
- Nehal M. El-koofy, Aya M. Fattouh, Areef Ramadan, Mohamed A. Elmonem, Dina H. Hamed
- Clin Exp Pediatr. 2022;65(8):410-416. Published online December 8, 2021
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In children with primary dyslipidemia, functional myocardial abnormalities can occur at young age, including diastolic functional impairment of both ventricles and narrowing of the aortic valve and the sinus of Valsalva. Echocardiographic evaluations of high-risk children may be as important as biochemical evaluations.
- Editorial
- Gastroenterology
- Is there a link between social media usage and functional gastrointestinal disorders in children? (484 times)
- Hae Jeong Lee
- Clin Exp Pediatr. 2023;66(4):169-170. Published online March 23, 2023
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Social media use has potential benefits and risks, including links to adverse health problems in children such as functional gastrointestinal disorders (FGIDs). Screen time control, emotional support, and parental guidance can help children navigate social media safely and reduce the risk of developing FGIDs.
- Neurology
- Cerebrospinal fluid biomarkers in various pediatric neurologic diseases (481 times)
- Jeongho Lee
- Clin Exp Pediatr. 2022;65(2):81-82. Published online January 6, 2022
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Cerebrospinal fluid (CSF) has many important biomarkers that are commonly analyzed in pediatric neurologic diseases, including central nervous system infection and inflammation. Neurologic disease in pediatrics is difficult to diagnosis, there are challenges in developing CSF profiles. Some biomarkers are expected to help differential diagnosis.
- Endocrinology
- Low bone mineral density can occur in children after shortterm systemic glucocorticoid treatment (481 times)
- Moon Bae Ahn
- Clin Exp Pediatr. 2022;65(6):300-301. Published online April 27, 2022
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Osteoporosis diagnosed in children with chronic diseases is a major endocrine complication triggered by the disease itself or its treatment. Although age upon starting osteotoxic agents and the their duration of use are vital contributors, spontaneous recovery of bone mass following treatment completion is a privilege of this specific age group. For any patients short-term glucocorticoid therapy, bone health screening is the next step.
- Neurology
- Understanding the usefulness of electroencephalography source localization (479 times)
- Bo Lyun Lee
- Clin Exp Pediatr. 2023;66(5):210-211. Published online April 18, 2023
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· Electroencephalography (EEG) records brain activity with high temporal resolution.
· EEG source localization, combined with other functional or structural imaging methods, provides information about brain network and connectivity in clinical neuroscience.
· EEG source localization identifies brain location from electrical current sources in several neuropsychiatric diseases such as epilepsy, attention deficit/hyperactivity disorder, and anxiety disorders.
- Letter to the Editor
- Infection
- Chest x-ray findings in children with COVID-19: lesson learned from referral hospitals in Medan, North Sumatera, Indonesia (478 times)
- Andrew Limavady, Eka Airlangga, Ririe Fachrina Malisie, Ayodhia Pitaloka Pasaribu
- Clin Exp Pediatr. 2023;66(7):317-319. Published online May 16, 2023
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- Editorial
- Neurobehavior
- Impact of coronavirus disease 2019 on children’s health (476 times)
- Joon Won Kang
- Clin Exp Pediatr. 2022;65(10):498-499. Published online September 16, 2022
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· Coronavirus disease 2019 (COVID-19) has had an enormous impact on mental health and other aspects of children’s health.
· The prevalence of anxiety, depression, and posttraumatic stress disorder in children and adolescents have increased in the COVID-19 era.
· Cooperation among parents, guardians, academic societies, and the government is needed to maintain the mental health of children and adolescents.
- Infection
- Effects of nonpharmaceutical interventions for coronavirus disease 2019 (468 times)
- Jae Hong Choi
- Clin Exp Pediatr. 2022;65(5):250-251. Published online March 22, 2022
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∙ Nonpharmaceutical interventions (NPIs) have decreased the incidence of various infectious diseases, including coronavirus disease 2019 (COVID-19).
∙ During the 2-year COVID-19 pandemic, NPIs changed patients’ daily lives, and the impact on mental health was notable.
∙ The effects of NPIs were evaluated in detail, considering both infections and mental health.
- Letter to the Editor
- Other
- Evaluation of simulation-based ultrasound course for pediatricians: a starting point for future training curriculum (464 times)
- Chon In Kuok, Avis Siu Ha Leung, Jonan Chun Yin Lee, Winnie Kwai Yu Chan
- Clin Exp Pediatr. 2022;65(1):53-55. Published online July 28, 2021
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Question: Simulation-based ultrasound training is becoming more popular. Is there a role for pediatricians in such training programs?
Finding: Our program received promising feedback from its participants. Self-rated confidence in image interpretation and ultrasound-guided catheter insertion improved after the simulation. Participants reported a higher preference for performing ultrasound scans before radiologist assessment.
Meaning: Ultrasound training can be considered as part of the pediatric training curriculum in the future.
- Correspondence and Reply
- Neurobehavior
- Association between polycystic ovary syndrome and risk of attention-deficit/hyperactivity disorder in offspring: a meta-analysis (463 times)
- Hadith Rastad, Mahnaz Seifi Alan
- Clin Exp Pediatr. 2022;65(3):152-152. Published online February 17, 2022
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- Editorial
- Endocrinology
- Is type 1 diabetes related to coronavirus disease 2019 in children? (460 times)
- Minsun Kim
- Clin Exp Pediatr. 2022;65(5):252-253. Published online March 29, 2022
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· Evidence shows that patients with type 1 diabetes have been severely affected by coronavirus disease 2019 (COVID-19) in various ways.
· Although there is no reliable evidence that COVID-19 worsens or induces diabetes, it can impair β-cell insulin secretion and glucose control by inducing inflammation and cytokine production.
· A study is needed of the short- and long-term relationship between diabetes and COVID-19 in the Korean pediatric population.
- Pediatricians must consider familial environment when diagnosing and managing childhood obesity (456 times)
- Young Suk Shim
- Clin Exp Pediatr. 2022;65(1):31-32. Published online April 19, 2021
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•The prevalence of childhood obesity is increasing worldwide, including in the Republic of Korea, creating a major public healthissue.
•Accumulated evidence indicates a strong relationship between parentalandchildobesity.
•A family-based approach is indicated to prevent and manage childhoodandadultobesity.
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Impact Factor3.2
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8.02023CiteScore94nd percentilePowered by
