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Review Article
Nephrology (Genitourinary)
Kidney complications associated with COVID-19 infection and vaccination in children and adolescents: a brief review
Hee Sun Baek, Min Hyun Cho
Clin Exp Pediatr. 2023;66(10):424-431.   Published online June 28, 2023
Several observational studies have shown that acute kidney injury affects up to 46% of children and adolescents who develop severe postinflammatory responses, such as multisystem inflammatory syndrome in childhood, due to coronavirus disease 2019 (COVID-19). Although causality has not been established, some cases of glomerulopathy or nephrotic syndrome occurring after COVID-19 infection or vaccination have been reported. Therefore, kidney complications associated with these conditions in children and adolescents warrant attention.
Infection
Safety monitoring of COVID-19 vaccines: February 26, 2021, To June 4, 2022, Republic of Korea
Yeon-Kyeng Lee, Yunhyung Kwon, Yesul Heo, Eun Kyoung Kim, Seung Yun Kim, Hoon Cho, Seontae Kim, Mijeong Ko, Dosang Lim, Soon-Young Seo, Enhi Cho
Clin Exp Pediatr. 2023;66(10):415-423.   Published online June 13, 2023
· Enhanced safety monitoring system of coronavirus disease 2019 (COVID-19) vaccines were implemented to detect signals rapidly as part of the national COVID-19 vaccination program.
· As of June 4, 2023, reported adverse events after COVID-19 vaccination was 0.38% among 125,107,883 doses of COVID- 19 vaccines administered.
· Most reported adverse reactions after COVID-19 vaccinations have shown nonserious and mild intensity.
Global varicella vaccination programs
Young Hwa Lee, Young June Choe, Jia Lee, Eunseong Kim, Jae Young Lee, Kwan Hong, Yoonsun Yoon, Yun-Kyung Kim
Clin Exp Pediatr. 2022;65(12):555-562.   Published online November 2, 2022
It is important to evaluate its effectiveness at the national level and to determine the varicella vaccine schedule based on the evidence generated through the studies.
Effectiveness and safety of seasonal influenza vaccination in children with underlying respiratory diseases and allergy
Jin-Han Kang
Clin Exp Pediatr. 2014;57(4):164-170.   Published online April 30, 2014

Influenza causes acute respiratory infections and various complications. Children in the high-risk group have higher complication and hospitalization rates than high-risk elderly individuals. Influenza prevention in children is important, as they can be a source infection spread in their communities. Influenza vaccination is strongly recommended for high-risk children with chronic underlying circulatory and respiratory disease, immature infants, and children receiving...

Case Report
An adverse event following 2009 H1N1 influenza vaccination: a case of acute disseminated encephalomyelitis
Sang Teak Lee, Young June Choe, Won Jin Moon, Jin Woo Choi, Ran Lee
Clin Exp Pediatr. 2011;54(10):422-424.   Published online October 31, 2011

Acute disseminated encephalomyelitis (ADEM) is an inflammatory demyelinating disease of the central nervous system that typically follows an infection or vaccination and has a favorable long-term prognosis. We describe the first reported case of ADEM after vaccination against novel influenza A (H1N1). A previously healthy 34-month-old boy who developed ADEM presented with a seizure and left-sided weakness 5 days after...

Review Article
Update on pertussis and pertussis immunization
Jung Yun Hong
Clin Exp Pediatr. 2010;53(5):629-633.   Published online May 31, 2010

Pertussis is a highly contagious respiratory tract disease caused by Bordetella pertussis infection. The clinical manifestation of this infection can be severe enough to cause death. Although pertussis has been supposed to be a vaccine-preventable disease ever since the widespread vaccination of children against pertussis was started, since the 1990s, cases of pertussis and related fatalities are on the rise,...

Reemergence of mumps
Kyong Min Choi
Clin Exp Pediatr. 2010;53(5):623-628.   Published online May 31, 2010

The mumps virus is a single-stranded, non-segmented, negative-sense RNA virus belonging to the Paramyxoviridae family. Mumps is characterized by bilateral or unilateral swelling of the parotid gland. Aseptic meningitis is a common complication, and orchitis is also common in adolescents and adult men. Diagnosis is based on clinical findings, but because of high vaccination coverage, clinical findings alone are not...

Original Article
Mumps outbreak in Incheon, Korea, 2009
Seon Young Cho, Soo Young Lee, Jin Han Kang,, Hui Seung Hwang
Clin Exp Pediatr. 2010;53(1):67-71.   Published online January 15, 2010
Purpose : Recently, we have noticed an increase in the number of patients with mumps in Incheon, Korea. The aim of this study is to estimate the regional trend in mumps incidence and to evaluate the factors related to the recent increase. Methods : We reviewed the medical records of 66 patients with mumps who had been admitted to Incheon St....
Comparison of the seroconversion rate after primary hepatitis B vaccination and after revaccination of non-responders in full-term infants according to mother's HBsAg seropositivity
Jang Hee Kang, Jae Won Moon, Seung Hyun Kong, Kwang Su Hwang, Ji Sun Mok, Hyeon Jung Lee
Clin Exp Pediatr. 2008;51(11):1165-1171.   Published online November 15, 2008
Purpose : This study aimed to identify the true extent of non-responsiveness in full-term infants born from HBsAg-negative or HBsAg-positive mothers and vaccinated against hepatitis B virus (HBV) at 0, 1, and 6 months of age and to evaluate the effect of revaccination among non-responders. Methods : The study included 716 full-term infants born in 2004-2007. Of 716, 662 infants...
Erratum
About the new edition of child and adolescent health record book
Young Kyoo Shin
Clin Exp Pediatr. 2008;51(9):907-910.   Published online September 15, 2008
Recently we published new edition of `child & Adolescent health record book` considering easy usability and introduction of new vaccines. This record book has essential and important contents for caring our children and adolescents. Currently many people use various vaccination record books with wrong and poor contents. We suggest the campaign that every pediatrician must give our well made record...
Original Article
Clinical features of vaccination-associated thrombocytopenic purpura in children
Wan Soo Lee, Seung Taek Yu, Sae Ron Shin, Du Young Choi
Clin Exp Pediatr. 2008;51(6):610-615.   Published online June 15, 2008
Purpose : Idiopathic thrombocytopenic purpura (ITP) is a relatively common hematological disease in children. It generally occurs after exposure to a common viral infection episode; however, it may occasionally follow immunization with measles, measles-mumps-rubella (MMR), hepatitis B (HBV), influenza, diphtheria tetanus-pertussis (DTP), or chickenpox vaccines. In this study, the incidence, clinical characteristics, and treatment outcome of vaccination-associated ITP were investigated...
A study of the current(2003-2005) prevalence of anti-HBs and immunologic memory of hepatitis B vaccine in children from the central area of Korea
Young Won An, Eun Hee Chung, Insoo Rheem
Clin Exp Pediatr. 2006;49(6):630-634.   Published online June 15, 2006
Purpose : This study was conducted to assess the current(2003-2005) prevalence of anti-HBs and immunologic memory for Hepatitis B vaccine in children from the central area of Korea. Methods : Subjects were chosen from children and adolescents who received tests for hepatitis B surface antigen(HBsAg) and anti-HBs at Dankook University Hospital from March 2003 to May 2005. Among these, antibodies to...
A survey of parental knowledge of vaccination
Jung Woo Rhim, Chang Hwi Kim, Won Bae Lee, Jin Han Kang
Clin Exp Pediatr. 2006;49(3):251-257.   Published online March 15, 2006
Purpose : In this study, we created a questionnaire and collected answers concerning actual conditions of vaccination and parents' knowledge of vaccination issues, in order to find false knowledge of patients. We tried to give correct information and suggested the role of the pediatrician. Methods : We made questionnaires and collected answers from 466 parents from March 2004 to June...
Lymphadenitis following intradermal BCG vaccination
Hey Sung Baek, Ji Young Chang, Su Ji Moon, Sung Hee Oh
Clin Exp Pediatr. 2006;49(1):46-50.   Published online January 15, 2006
Purpose : Intradermal BCG vaccine has not well been accepted by pediatric practitioners due to BCG lymphadenitis. Therefore, this study was undertaken to find out the incidence of lymphadenitis following intradermal BCG vaccination and its clinical outcome. Methods : One thousand and fifty infants, who received intradermal BCG(French 1173 P2, Korea Tuberculosis Association) vaccination in the Well Baby Clinic of Hanyang...
A Questionnaire on Using Informed Consents of Parents or Guardians in Vaccination of Children
Seung-Hi Paik, Eun Hee Chung, Mie Ryung Uhm, Son Moon Shin, Woo Gill Lee, Mi Na Lee, Hoan Jong Lee
Clin Exp Pediatr. 2003;46(7):647-654.   Published online July 15, 2003
Purpose : This study was done to evaluate the parents' or guardians' compliance of obtaining individual informed consent before vaccination and the possible problems of using informed consent. Methods : One hundred and twelve children were randomly selected among 2,820 children who visited Samsung Cheil Hospital during July 2002. A questionnaire about using informed consent of vaccination was given to all...
Study on Vaccination State in Children : Jeonbuk Province, 2000
Ju Mi Choung, Jung Chul Kim, So Hee Eun, Pyoung Han Hwang, B. Nyhambat, P. Kilgore, Jung Soo Kim
Clin Exp Pediatr. 2002;45(10):1234-1240.   Published online October 15, 2002
Purpose : This study was carried out to obtain the vaccination rate and age appropriateness of vaccination in children under five years of age in Jeonbuk province. Methods : Eight hundred and fifty infants and children were enrolled in this study. Vaccination rate(Number of vaccinees/Number of subjects), places of vaccination, age appropriateness of vacination were examined by either vaccine record review or interview with...
Clinical Studies of Measles Prevalence in Western Kyungnam District in 2000
Byoung O Kwon, Hye Young Ju, Jeong Hee Kim, Hwang Jae Yoo, Chun Soo Kim
Clin Exp Pediatr. 2002;45(3):331-338.   Published online March 15, 2002
Purpose : To investigate the feature of the range of measles in 2000, we studied epidemics of the measles in western Kyungnam District. Methods : Among 489 patients under 15 years of age who visited or were admitted to in our hospital from January to December in 2000, we selected 344 patients whose measles IgM antibody was positive. We investigated age,...
MMR Immunization Rate and Related Factors - Findings from Repeated Surveys(1996, 1999) on Elementary School Students in Kyonggi Province, Korea -
Moran Ki, Moynghee Kim, Young-Jeon Shin, Boyoul Choi
Clin Exp Pediatr. 2001;44(4):375-388.   Published online April 15, 2001
Purpose : This study was carried out to obtain the immunization rate of MMR, and to know the related factors. Methods : Subjects of the study were 3,364 students of 8 elementary schools of Kyonggi province. Surveys accompanied with questionnaires were conducted in 1996 and 1999, respectively. Results : The salient features of the findings were as follows : The immunization rate...
Antibody Response and Adverse Reaction Following Immunization with MMR Vaccine Produced on Human Diploid Cells in Korean Children
Sung Hee Oh, Jin Han Kang, Young Mo Sohn, Hoan Jong Lee, Bok Yang Pyun, Chang Hwi Kim
Clin Exp Pediatr. 2000;43(4):489-495.   Published online April 15, 2000
Purpose : This prospective study was performed to evaluate the immunogenecity and safety of MMR vaccine(Triviraten Berna¢c) in Korea children. Methods : Seventy-three infants aged between 12 to 18 months were recruited from several university hospitals between December 1995 to June 1996. MMR vaccine(Triviraten Berna¢c) was administrered and blood was obtained before and 6-10 weeks after vaccination. IgG antibodies against measles,...
Effects of Hepatitis B Revaccination in Nonresponsive Children
Ui Chong Chong, Mi Ran Kim, Chong Young Park
Clin Exp Pediatr. 1999;42(6):778-782.   Published online June 15, 1999
Purpose : Hepatitis B virus infection is prevalent in Korea. Active immunization of Hepatitis B has been proceeded extensively for the last decade. This study was performed to estimate the negative rate of anti-HBs after immunization and to evaluate the effect of revaccination among Korean children between 1995 and 1997, as well as to determine a proper revaccination schedule. Methods :...
The Effect of Measles Vaccination Before Turning 1 Year-old on the Measles Antibody Response to Immunization with MMR
Soo Jung Choi, Young Jae Koh, Young Mo Soh, Hoan Jong Lee, Sung Hee Oh
Clin Exp Pediatr. 1998;41(7):909-916.   Published online July 15, 1998
Purpose : With the implementation of measles vaccination programs, the number of patients with measles has decreased. However, epidemics still occur with high morbidity in infants less than 1 year of age. This fact calls for the establishment of optimal preventive measures against measles. The study was carried out to determine the effect of measles vaccination on an infant immunized...
Effect of Simultaneous Administration of Hepatitis B Vaccine with DPT and Oral Polio Vaccine
Hyo Geun Ju, Young Youn Choi, Jae Sook Ma, Tai Ju Hwang
Clin Exp Pediatr. 1998;41(4):451-455.   Published online April 15, 1998
Purpose : The universal vaccination against hepatitis B during early infancy is the only effective way to control hepatitis B infection in highly endemic areas in Korea. The purpose of this study was to assess the effectiveness of simultaneous hepatitis B vaccination with DPT and oral polio at 2, 4, 6 months of age in babies of HBs antigen negative mothers. Methods : One...
Humoral and Cell Mediated Immune Response After Immunization with Varicella Vaccine(Oka/LG)
Young Mo Sohn, Hye Ok Roh, Mi Lim Goo, Bok Ryeon Park, Joo Hong Park, Gook Jin Lim
Clin Exp Pediatr. 1998;41(2):170-178.   Published online February 15, 1998
Purpose : We evaluated the humoral and cellular immune response to varicella-zoster virus after vaccination with varicella vaccine(Oka/LG strain). Methods : The seroprevalence rate of fluorescent antibody to membrane antigen(FAMA) was evaluated among 178 children and 15 adults. After vaccination, seroconversion rate of FAMA, varicella-zoster virus(VZV) specific IgG and cell mediated immune response to glycoprotein Ⅰwas performed. Results : The seropositive rate...
The Clinical Study on Conversion Rate of Mantoux Test, Change of Local Lesion and Complication after Multipuncture BCG Vaccination in Neonates
Myung Ho Oh, Kee Hyuck Kim, Jae Gun Sim
Clin Exp Pediatr. 1997;40(8):1120-1130.   Published online August 15, 1997
Purpose : Ugly ulcer and keloid formation of injection site has sometimes been a problem in Korea from the cosmetic point of view in intradermal vaccination. Since 3 or 4 years ago, multipuncture BCG vaccination has been used in Korea, there are no data and information about multipuncture BCG vaccination. We therefore performed this study to evaluate of conversion rate, complication and to make...
Epidemiology of Varicella in Korea Based on Pediatrician's Office Practice
Dong Jun Kim, Hyeon Soo Park, Sang Yun Lee, Kee Surk Park, Taik Kill Kim, Young Hoon Song, Jin Choi, Jin Woo Han, Young Suk Song, Tae Jin Park, Hong Kun Kim, Soo Yup Lee, Sun Ho Lee, Hak Won Kim, Sung Hee Oh
Clin Exp Pediatr. 1997;40(5):620-628.   Published online May 15, 1997
Purpose : Although varicella outbreakes have frequently occured, the epidemiology of varicella in Korea has not well been delineated. Furthermore without enough investigation with regard to safety and efficacy of varicella vaccine in Korean population, thevaccine has begun to be used in healthy children. Therefore the authors analized the clinical features of patients diagnosed of varicella to aid in understanding...
Conversion Rates of Tuberculin Test according to BCG Vaccination Methods
Woo Sung Kim, Chang Hwi Kim, Dong Hwan Lee, Sang Mann Shin
Clin Exp Pediatr. 1997;40(4):489-496.   Published online April 15, 1997
Purpose : Tuberculosis, a major public health problem, is an important cause of childhood morbidity and mortality in developing countries. To decline the tuberculosis morbidity rate, active BCG vaccination is performed worldwide. Recently percutaneous multiple puncture technique of BCG vaccination was introduced and used because of side effects of intradermal BCG vaccination such as scar, local ulceration, regional suppurative lymphadenitis....
Changes of Anti-H.influenzae Type b IgG in the Sera of Korean Infants and Children after Birt
Jong Man Park, Keoung Hie Moon, Kyung Mee Lee, Sun Jun Kim, Soo Chul Cho, Jung Soo Kim
Clin Exp Pediatr. 1997;40(2):181-188.   Published online February 15, 1997
Purpose : Most of invasive Haemophilus influenzae diseases occur in children under 5 years of age, and are due almost exclusively to type b strain. Although antibodies to several surface antigens of H.influenzae play a role in conferring immunity, antibody to the type b capsular polysaccharide appeared to have the most important protective functions. However, the antibody response to vaccines or natural...
The Report of the Epidemiology of Measles which Prevailed in the Kyungi-Incheon Districts from July, 1993 & June,1994
Sang Uk Moon, Sung Dong Choi, Seng Yeon Jung, Byung Kyu Seo, Won Bae Lee, Jin Han Kang, Kyung Soo Lee
Clin Exp Pediatr. 1996;39(10):1378-1384.   Published online October 15, 1996
Purpose : As a result of the development and the supply of vaccination, the epochal progress in vaccination against measles has been made. Nevertheless measles intermittent prevalence throughout the world was reported and measles prevailed throughout country in 1993 & 1994. So, we studied the epidemics of measles which prevailed in the Kyungi-Incheon districts and then evaluated the effects of the present vaccination indirectly...
Recent Changesin Prevalence of Hepatitis B Viral Markers in Preschool Children in Seoul,1995
Yon Ho Choe, Jeong Kee Seo, Jeong Hwan Yun, Hyo Seok Lee
Clin Exp Pediatr. 1996;39(9):1254-1259.   Published online September 15, 1996
Purpose : A nationwide hepatitis B vaccination publicity campaign and program was launched in 1988 in Korea. This survey was designed to evaluate the recent changes of the positive rates of hepatitis B surface antigen and antibody in sampled preschool children living in Seoul, 1995. Methods : Study population consisted of 218 preschool children aged 2 to 5 years. Most of them had been...
Comparison of Measles Specific IgG in the Sera of Infants and Children after Vaccination of Measles
Young Kyoo Shin, Hyung Suk Kim, Ji Tai Choung, Young Chang Tockgo
Clin Exp Pediatr. 1996;39(5):625-630.   Published online May 15, 1996
Purpose : After recent epidemics of measles in Korea, Korean Pediatric Society recommended 2 dose measles vaccination schedule instead of 1 dose since 1991. However, the studies that supported the modification of vaccination schedule were insufficient yet. This study was performed to evaluate the vaccination efficacy of 1 dose and 2 dose vaccination. Methods : One dose vaccination group consisted of 19 infants(mean:...