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Review Article
General Pediatrics
The 2017 Korean National Growth Charts for children and adolescents: development, improvement, and prospects
Jae Hyun Kim, Sungha Yun, Seung-sik Hwang, Jung Ok Shim, Hyun Wook Chae, Yeoun Joo Lee, Ji Hyuk Lee, Soon Chul Kim, Dohee Lim, Sei Won Yang, Kyungwon Oh, Jin Soo Moon; for the Committee for the Development of Growth Standards for Korean Children and Adolescents, the Committee for School Health and Public Health Statistics; the Committee for School Health and Public Health Statistics; the Korean Pediatric Society, and Division of Health and Nutrition Survey; Korea Centers for Disease Control and Prevention
Clin Exp Pediatr. 2018;61(5):135-149.   Published online May 28, 2018

Growth charts are curves or tables that facilitate the visualization of anthropometric parameters, and are widely used as an important indicator when evaluating the growth status of children and adolescents. The latest version of the Korean National Growth Charts released in 2007 has raised concerns regarding the inclusion of data from both breastfed and formula-fed infants, higher body mass index...

Original Article
Endocrinology
The association of total blood mercury levels and overweight among Korean adolescents: analysis of the Korean National Health and Nutrition Examination Survey (KNHANES) 2010–2013
Yi-Yeon Shin, In-Kyung Ryu, Mi-Jung Park, Shin-Hye Kim
Clin Exp Pediatr. 2018;61(4):121-128.   Published online April 23, 2018
Purpose

Obesity has been associated with higher total blood mercury levels, based on animal studies; however, studies that focus on children and adolescents are lacking. We aimed to assess the association between total blood mercury levels and the incidence of overweight and abdominal obesity in Korean adolescents.

Methods

The study population comprised 1,567 adolescents (793 boys and 774 girls; aged 10–19 years), who...

Cardiology
Radiofrequency catheter ablation of atrioventricular nodal reentry tachycardia in children and adolescents: a single center experience
Myung Chul Hyun
Clin Exp Pediatr. 2017;60(12):390-394.   Published online December 22, 2017
Purpose

Atrioventricular nodal reentry tachycardia (AVNRT) is less common in pediatric patients than in adult patients. Thus, data for pediatric AVNRT patients are insufficient. Hence, we aimed to analyze the patient characteristics, treatment, and any recurrences in pediatric AVNRT patients.

Methods

We reviewed the records of 50 pediatric AVNRT patients who had undergone radiofrequency catheter ablation (RFCA) between January 1998 and December 2016...

General Pediatrics
The correlation of depression with Internet use and body image in Korean adolescents
Chang Hoon Lim, Eun Ji Kim, Jong Hyun Kim, Jue Seong Lee, Yoon Lee, Sang Hee Park
Clin Exp Pediatr. 2017;60(1):17-23.   Published online January 24, 2017
Purpose

To examine the correlation of depression with Internet use and body image perception, and to analyze the risk factors of depression in a total of 920 students in Seoul, Korea.

Methods

Students were recruited by contacting school principals and teachers and were encouraged to fill out a self-report questionnaire designed specifically for this study in July of 2008.

Results

Female participants had an increased...

Review Article
Infection
Recommended immunization schedule for children and adolescents: Immunization Guideline (8th edition) released by the Korean Pediatric Society in 2015
Jong-Hyun Kim, Eun Hwa Choi, Su Eun Park, Yae-Jean Kim, Dae Sun Jo, Yun-Kyung Kim, Byung-Wook Eun, Jina Lee, Soo-Young Lee, Hyunju Lee, Ki Hwan Kim, Kyung-Hyo Kim
Clin Exp Pediatr. 2016;59(12):461-465.   Published online December 31, 2016

This report includes the recommended immunization schedule table for children and adolescents based on the 8th (2015) and revised 7th (2012) Immunization Guidelines released by the Committee on Infectious Diseases of the Korean Pediatric Society (KPS). Notable revised recommendations include: reorganization of the immunization table with a list of vaccines on the vertical axis and the corresponding age on the...

Case Report
Neurology
Painful legs and moving toes syndrome in a 16-year-old girl
Seung Soo Kim, Yong Seung Hwang, Young Chang Kim
Clin Exp Pediatr. 2016;59(9):381-383.   Published online September 21, 2016

Painful legs and moving toes (PLMT) syndrome is characterized by spontaneous movements of the digits and pain in one or both lower extremities. Of the reported cases, a majority of the patients was female, and the mean age of onset was 58 years. Only one pediatric case has been reported so far. Herein, we report the first adolescent case of...

Original Article
Endocrinology
Lipopolysaccharide-binding protein plasma levels as a biomarker of obesity-related insulin resistance in adolescents
Ki Eun Kim, Young Sun Cho, Kyung Suk Baek, Lan Li, Kwang-Hyun Baek, Jung Hyun Kim, Ho-Seong Kim, Youn Ho Sheen
Clin Exp Pediatr. 2016;59(5):231-238.   Published online May 31, 2016
Purpose

Lipopolysaccharide-binding protein (LBP) is a 65-kDa acute phase protein, derived from the liver, which is present in high concentrations in plasma. Data regarding the association between circulating plasma LBP levels and obesity-related biomarkers in the pediatric population are scarce. We aimed to determine whether there was a difference in plasma LBP levels between overweight/obese and normal-weight adolescents and to assess...

Emergency Medicine
A nationwide study of children and adolescents with pneumonia who visited Emergency Department in South Korea in 2012
Chang Hyu Lee, Youn Kyoung Won, Eui-Jung Roh, Dong In Suh, Eun Hee Chung
Clin Exp Pediatr. 2016;59(3):132-138.   Published online March 31, 2016
Purpose

Acute respiratory infection, particularly pneumonia, is the most common cause of hospitalization and death among children in developing nations. This study aimed to investigate the characteristics of children and adolescents with pneumonia who visited Emergency Department (ED) in South Korea in 2012.

Methods

We analyzed National Emergency Department Information System (NEDIS) records from 146 EDs in South Korea for all pediatric patients...

General Pediatrics
Reference values of lead in blood and related factors among Korean adolescents: the Korean National Health and Nutrition Examination Survey 2010-2013
Min-Gyu Choi, Mi-Jung Park, Shin-Hye Kim
Clin Exp Pediatr. 2016;59(3):114-119.   Published online March 31, 2016
Purpose

This study aimed to assess the reference values and factors influencing blood lead levels among Korean adolescents.

Methods

The study population consisted of 1,585 adolescents (801 males, 784 females; aged 10-19 years) who participated in the Korea National Health and Nutrition Examination Survey 2010-2013. We analyzed blood lead concentrations in relation to demographic/lifestyle characteristics for all participants. "Reference values" of blood lead...

Endocrinology
Impact of lifestyle factors on trends in lipid profiles among Korean adolescents: the Korea National Health and Nutrition Examination Surveys study, 1998 and 2010
Shin-Hye Kim, Young-Hwan Song, Sangshin Park, Mi-Jung Park
Clin Exp Pediatr. 2016;59(2):65-73.   Published online February 29, 2016
Purpose

Only a few studies have explored nationwide trends in lipid profiles among Asian adolescents. We aimed to assess trends in lipid profiles and the associated lifestyle factors among Korean children.

Methods

We analyzed data for 2,094 adolescents who were aged 10–18 years and had participated in the Korea National Health and Nutrition Examination Surveys in 1998 and 2010.

Results

During 1998–2010, the prevalence of...

Case Report
Infection
Tuberculosis-associated hemophagocytic lymphohistiocytosis in adolescent diagnosed by polymerase chain reaction
Ju-Hee Seo, Jun Ah Lee, Dong Ho Kim, Joongbum Cho, Jung Sub Lim
Clin Exp Pediatr. 2016;59(1):43-46.   Published online January 22, 2016

We present a case of tuberculosis-associated hemophagocytic lymphohistiocytosis in a 14-year-old girl. The patient presented with weight loss, malaise, fatigue, prolonged fever, and generalized lymphadenopathy. Laboratory investigation revealed pancytopenia (white blood cells, 2,020 cells/µL; hemoglobin, 10.2 g/dL; platelets, 52,000 cells/µL), hypertriglyceridemia (229 mg/dL), and hyperferritinemia (1,420 ng/mL). Bone marrow biopsy showed a hypocellular bone marrow with a large numbers of...

Original Article
Analysis of clinical characteristics and causes of chest pain in children and adolescents
Ji Hye Chun, Tae Hyeong Kim, Mi Young Han, Na Yeon Kim, Kyung Lim Yoon
Clin Exp Pediatr. 2015;58(11):440-445.   Published online November 22, 2015
Purpose

Chest pain is common in children and adolescents and is a reason for referral to pediatric cardiologists. Although most cases of chest pain in these age groups are benign and do not require treatment, timely diagnosis is important not to miss life-threatening diseases requiring prompt treatment. We investigated certain clinical characteristics that may be useful in the diagnosis of such...

Review Article
Haploidentical hematopoietic stem cell transplantation in children and adolescents with acquired severe aplastic anemia
Ho Joon Im, Kyung-Nam Koh, Jong Jin Seo
Clin Exp Pediatr. 2015;58(6):199-205.   Published online June 22, 2015

Severe aplastic anemia (SAA) is a life-threatening disorder for which allogeneic hematopoietic stem cell transplantation (HSCT) is the current available curative treatment. HSCT from matched sibling donors (MSDs) is the preferred therapy for children with acquired SAA. For patients who lack MSDs, immunosuppressive therapy (IST) is widely accepted as a first-line treatment before considering HCT from an unrelated donor (URD)....

Original Article
Association between serum alanine aminotransferase level and obesity indices in Korean adolescents
Moon Bae Ahn, Woo Ri Bae, Kyung Do Han, Won Kyoung Cho, Kyoung Soon Cho, So Hyun Park, Min Ho Jung, Byung Kyu Suh
Clin Exp Pediatr. 2015;58(5):165-171.   Published online May 22, 2015
Purpose

To analyze the correlation between serum alanine aminotransferase (ALT) and obesity indices including body mass index (BMI), body fat percentage (BFP), total fat mass (FM), truncal fat mass (TFM), waist circumference (WC), and waist-to-height ratio (WHtR) in Korean adolescents.

Methods

This was a cross-sectional study based on data derived from the 2010-2011 Korean National Health and Nutrition Examination Surveys (KNHANES). Subjects were...

Review Article
Osteosarcoma in Korean children and adolescents
Jun Ah Lee
Clin Exp Pediatr. 2015;58(4):123-128.   Published online April 22, 2015

Osteosarcoma is the most frequent primary bone tumor. Advances in combination chemotherapy and surgical technique have greatly improved the survival of patients with osteosarcoma. In Korea, improvements in osteosarcoma treatment have been made over the past two decades. The 5-year event-free survival rate of Korean children and adolescents with localized disease is 64.6%, comparable to that of American or European...

Original Article
Associations of matrix metalloproteinase (MMP)-8, MMP-9, and their inhibitor, tissue inhibitor of metalloproteinase-1, with obesity-related biomarkers in apparently healthy adolescent boys
Youn Ho Shin, Ki Eun Kim, Yong-Jae Lee, Jae-Hwan Nam, Young Mi Hong, Hye-Jung Shin
Clin Exp Pediatr. 2014;57(12):526-532.   Published online December 31, 2014
Purpose

Matrix metalloproteinases (MMPs) have been implicated in atherosclerosis, and therefore, are considered risk factors for metabolic dysfunction in adults. However, there is little data on circulating levels of MMPs and tissue inhibitors of MMPs (TIMPs) with regard to obesity-related biomarkers in the general adolescent population. In the present study, we determined the associations of MMP-8, MMP-9, and TIMP-1 levels and...

Lifestyle modifications in an adolescent dormitory: a clinical trial
Ibrahim Abu-Kishk, Michal Alumot-Yehoshua, Gadi Reisler, Shai Efrati, Eran Kozer, Keren Doenyas-Barak, Michal Feldon, Zahi Dagan, Rami Reifen, Matitiahu Berkovitch
Clin Exp Pediatr. 2014;57(12):520-525.   Published online December 31, 2014
Purpose

Childhood obesity is an increasing public health issue worldwide. We examined dietary patterns among adolescents in a dormitory school, identified obese adolescents and tried to intervene to improve food habits and physical activity.

Methods

We conducted an experimental prospective longitudinal study based on 36 obese (body mass index [BMI]≥95th percentile) adolescents (aged 12-18 years) compared with controls (healthy children: normal age-appropriate BMI...

Case Report
Multifocal kaposiform hemangioendothelioma of soft tissue with bilateral pulmonary involvement in an adolescent
Roxana Azma, Samin Alavi, Maliheh Khoddami, Mohammad Taghi Arzanian, Armin Nourmohammad, Sadaf Esteghamati
Clin Exp Pediatr. 2014;57(11):500-504.   Published online November 30, 2014

Kaposiform hemangioendothelioma (KHE) is a rare, locally aggressive vascular tumor of intermediate malignancy with resemblance to Kaposi sarcoma. It occurs predominantly in pediatric age groups as a cutaneous lesion with focal infiltration into the adjacent soft tissue and bone. Although visceral involvement is very uncommon, several cases with bone, retroperitoneal, or mediastinal involvement have been described. KHE has been reported...

Original Article
Prevalence of restless legs syndrome and sleep problems in Korean children and adolescents with attention deficit hyperactivity disorder: a single institution study
Soonhak Kwon, Youngsoo Sohn, Seong-Hoon Jeong, Un-Sun Chung, Hyeeun Seo
Clin Exp Pediatr. 2014;57(7):317-322.   Published online July 23, 2014
Purpose

Attention deficit hyperactivity disorder (ADHD) is a common disorder in school-aged children. Patients with restless legs syndrome (RLS) often present with ADHD symptoms and vice versa. This study was the first to attempt to identify the prevalence of RLS and sleep problems in children with ADHD in Korea.

Methods

Patients diagnosed with ADHD were asked to complete a sleep questionnaire. The sleep...

Baseline heart rate variability in children and adolescents with vasovagal syncope
Sun Hee Shim, Sun-Young Park, Se Na Moon, Jin Hee Oh, Jae Young Lee, Hyun Hee Kim, Ji Whan Han, Soon Ju Lee
Clin Exp Pediatr. 2014;57(4):193-198.   Published online April 30, 2014
Purpose

This study aimed to evaluate the autonomic imbalance in syncope by comparing the baseline heart rate variability (HRV) between healthy children and those with vasovagal syncope.

Methods

To characterize the autonomic profile in children experiencing vasovagal syncope, we evaluated the HRV of 23 patients aged 7-18 years and 20 healthy children. These children were divided into preadolescent (<12 years) and adolescent groups....

The association of blood pressure with body mass index and waist circumference in normal weight and overweight adolescents
Young-Hwan Song
Clin Exp Pediatr. 2014;57(2):79-84.   Published online February 24, 2014
Purpose

Overweight can be defined by the body mass index (BMI) and is likely associated with an increased cardiovascular disease risk. However, waist circumference (WC), a central adiposity index, may be a better indicator of cardiovascular disease risk. Studies comparing the effects of BMI and WC on cardiovascular risk factors, such as high blood pressure (BP), are rare in adolescents.

Methods

We analyzed...

The correlation of blood pressure with height and weight in Korean adolescents aged 10-19 years; The Korean National Health and Nutrition Examination Surveys (2009-2011)
Young-Hwan Song
Clin Exp Pediatr. 2014;57(1):35-40.   Published online January 31, 2014
Purpose

Height-specific blood pressure (BP) is the standard parameter used to diagnose childhood hypertension. However, there has been some argument that weight may be a better variable than height in the reference BP standards. Therefore, before assessing the BP status using the reference BP standards, a basic understanding of the fundamental association of weight and height with BP is required.

Methods

In the...

The relationships of body mass index, waist-to-height ratio, and body fat percentage with blood pressure and its hemodynamic determinants in Korean adolescents: a school-based study
Na Young Kim, Young Mi Hong, Jo Won Jung, Nam Su Kim, Chung Il Noh, Young-Hwan Song
Clin Exp Pediatr. 2013;56(12):526-533.   Published online December 20, 2013
Purpose

Obesity is an important risk factor for hypertension in adolescents. We investigated the relationship of obesity-related indices (body mass index [BMI], waist-to-height ratio [WHR], and body fat percentage [%BF]) with blood pressure and the hemodynamic determinants of blood pressure in Korean adolescents.

Methods

In 2008, 565 adolescents, aged 12-16 years, were examined. The %BF of the participants was measured by bioelectrical impedance...

Review Article
The promotion of mental health and the prevention of mental health problems in child and adolescent
Sun Mi Cho, Yun Mi Shin
Clin Exp Pediatr. 2013;56(11):459-464.   Published online November 27, 2013

Improving mental health and reducing the burden of mental illness are complementary strategies which, along with the treatment and rehabilitation of people with mental disorders, significantly improve population health and well-being. A Institute of Medicine report describes a range of interventions for mental disorders that included treatment and maintenance, reserving the term "prevention" for efforts that occur before onset of...

Vitamin D status and childhood health
Youn Ho Shin, Hye Jung Shin, Yong-Jae Lee
Clin Exp Pediatr. 2013;56(10):417-423.   Published online October 31, 2013

Vitamin D is an essential component of bone and mineral metabolism; its deficiency causes growth retardation and skeletal deformities in children and osteomalacia and osteoporosis in adults. Hypovitaminosis D (vitamin D insufficiency or deficiency) is observed not only in adults but also in infants, children, and adolescents. Previous studies suggest that sufficient serum vitamin D levels should be maintained in...

Original Article
The results of cardiopulmonary exercise test in healthy Korean children and adolescents: single center study
Jun-Sook Lee, So-Ick Jang, Seong-Ho Kim, Sang-Yun Lee, Jae-Suk Baek, Woo-Sup Shim
Clin Exp Pediatr. 2013;56(6):242-246.   Published online June 21, 2013
Purpose

The cardiopulmonary exercise test (CPET) is an important clinical tool for evaluating exercise capacity and is frequently used to evaluate chronic conditions including congenital heart disease. However, data on the normal CPET values for Korean children and adolescents are lacking. The aim of this study was to provide reference data for CPET variables in children and adolescents.

Methods

From August 2006 to...

Review Article
Recommended immunization schedule for children and adolescents: the Korean Pediatric Society, 2013
Dae Sun Jo, Jong-Hyun Kim, Eun Hwa Choi, Su Eun Park, Yae-Jean Kim, Yun Kyung Kim, Jina Lee, Byung Wook Eun, Soo Young Lee, Hyunju Lee, Ki Hwan Kim, Kyung-Hyo Kim
Clin Exp Pediatr. 2013;56(6):231-234.   Published online June 21, 2013

This article contains the recommended immunization schedule by the Committee on Infectious Diseases of the Korean Pediatric Society, updated in March 2013, when Haemophilus influenzae type b vaccine is now included in the National Immunization Program in Korea. It also includes catch-up immunization schedule for children and adolescents who are behind the recommended schedule. These schedules are a minor revision...

The role of the pediatrician in youth violence prevention
Soon Ki Kim, Nam Su Kim
Clin Exp Pediatr. 2013;56(1):1-7.   Published online January 29, 2013

School bullying has become a major social problem in Korea after the emergence of media reports on children who committed suicide after being victimized by bullies. In this article, we review the characteristics of bullying, and investigate the role of the pediatrician in the prevention of and intervention against bullying and school violence. Bullying can take on many forms such...

Original Article
Dietary patterns and metabolic syndrome risk factors among adolescents
Hyojee Joung, Soyoung Hong, Yoonju Song, Byung Chul Ahn, Mi Jung Park
Clin Exp Pediatr. 2012;55(4):128-135.   Published online April 30, 2012
Purpose

Unbalanced diets and decreased physical activity have contributed to increased prevalence of obesity and metabolic syndrome in adolescents. We have performed a systematic review and data analysis to examine the association between dietary pattern and metabolic syndrome risk factors in adolescents.

Methods

We searched the PubMed and BioMedLib databases for appropriate articles published during the past 10 years and selected 6 articles....

Review Article
Infectious diseases in children and adolescents in the Republic of Korea; Past & recent status
Jong-Hyun Kim
Clin Exp Pediatr. 2011;54(12):489-500.   Published online December 31, 2011

Compared to the past decades, in recent decades, environmental and hygienic conditions in the Republic of Korea have improved along with socioeconomic developments, and the incidence of most infectious diseases, especially vaccine-preventable diseases, has greatly decreased due to active immunization with the developed level of health care. However, the incidence of some diseases has been increasing, and new diseases have...



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