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Original Article
Oscillometric Blood Pressure of Upper and Lower Extremities and Aortic Blood Flow Velocity in Neonates
Sang Young Bae, Hae Soon Kim, Se Jung Sohn, Young Mi Hong
Clin Exp Pediatr. 2000;43(4):484-488.   Published online April 15, 2000
Purpose : We studied the blood pressure difference between the upper and lower extremities in healthy newborn infants and the effect of isthmic narrowing of the aorta on making a possible difference. Methods : The blood pressure was measured with an oscillometric blood pressure device from four extremities of 62 healthy infants aged 1-15 days. A Doppler echocardiography was performed for...
Apoptosis of Peripheral Blood Mononuclear Cells in Different Ages of Normal Children
Dong Soo Kim, Hyun Young Kim, John A Linton
Clin Exp Pediatr. 2000;43(4):463-469.   Published online April 15, 2000
Purpose : To survive in an ecological environment, an individual must develop immunity to various antigens. Therefore, populations of peripheral blood mononuclear cells(PBMC) in humans change continuously with growth. The object of this study is to evaluate the apoptosis of peripheral blood mononuclear cells(PBMC) in normal children of different ages. Methods : PBMC were isolated from the study groups. Ten...
Changes in Arterial Blood Gas in Crying Neonates
Yeo Hyang Kim, Heng Mi Kim
Clin Exp Pediatr. 1999;42(11):1496-1501.   Published online November 15, 1999
Purpose : Arterial blood gas and pH measurements are the standard by which adequacy of oxygenation and ventilation are assessed. The major problem with arterial punctures is that they can rarely be done without disturbing the neonates. Crying during arterial puncture usually results in change in respiratory patten and thus may result in significant changes in blood gas values Methods :...
The Use of Quadruple Blood Bags Transfusion of Low Birth Weight Neonates
Sang Hoon Lee, Jean Yoon, Yang Park, Sung Kyu Lee, Hee Chung Kim, Woo Sup Shim
Clin Exp Pediatr. 1999;42(8):1122-1129.   Published online August 15, 1999
Purpose : Low-birth-weight(LBW) neonates often need multiple transfusions during their neonatal period. The routine use of the 500ml mono-bag system in Korea, even in neonatal transfusions, results in a great waste of blood and exposes the neonate to multiple blood donors. To reduce the waste of blood and the number of exposures, we used quadruple blood bags in the transfusion...
Effect of Fetal Cardiac Bypass on Fetal Cardiovascular System - Fetal Lamb Study -
Jung Yun Choi, June Huh, Yong Jin Kim, Won Gon Kim, Jeong Ryul Lee, Chong Sung Kim
Clin Exp Pediatr. 1999;42(7):943-952.   Published online July 15, 1999
Purpose : This study was aimed to evaluate the feasibility of echo-Doppler study on fetal lamb, analyse the distribution of blood flow before and after fetal cardiac bypass, and consequently assess the effect of fetal cardiac bypass on the fetal cardiovascular system. Methods : Ten fetal lambs at 120 to 150 days of gestation which underwent cardiac bypass for 30 minutes...
Inhibitory Effects of Dexamethasone on Production IL-1α and TNF-α in Peripheral Blood Mononuclear Cells
Eun Ae Park, Kyung Hyo Kim, Gyoung Hee Kim
Clin Exp Pediatr. 1999;42(7):921-927.   Published online July 15, 1999
Purpose : IL-1α and TNF-α have a seminal role in the intial events of inflammation. An area of intense interest is the assessment of new therapeutic modalities that regulate inflammatory response in acute bacterial infection. We conducted this study to compare the inhibitory effects of dexamethasone on the secretion of proinflammatory cytokines, such as IL-lα and TNF-α from cord...
Whole Blood and Plasma Vitamin C Level in Healthy Middle and High School Students in Chinju
Yang-Suk Jung, Jae-Young Lim, Eun-A Kim, Yun-Kyeong Cho, Chan-Hoo Park, Hyang-Ok Woo, Hee-Shang Youn, Gyung-Hyuck Ko, Seung-Chul Baik, Woo-Kon Lee, Myung-Je Cho, Kwang-Ho Rhee
Clin Exp Pediatr. 1999;42(6):748-755.   Published online June 15, 1999
Purpose : Recommended dietary allowance of vitamin C was determined without considering the important function of vitamin C as a first-line antioxidant. We measured the whole blood and plasma vitamin C concentrations of healthy middle and high school students in Chinju to assess the optimal daily vitamin C requirement in these age groups. Methods : Whole blood and plasma vitamin C...
Neonatal Cord Blood Leptin : Its Relationship to Birth Weight
Byung Churl Lee, In Kyung Sung, Byung Kyu Suh, Moon Young Song
Clin Exp Pediatr. 1999;42(5):637-643.   Published online May 15, 1999
Purpose : The purpose of this study was to correlate birth weight, skinfold thickness, gestational age, BMI and ponderal index of neonates and maternal status with cord serum leptin concentration. Methods : Sixty newborns were enrolled in this study. Standard growth curves were used to categorize infants as appropriate(AGA), large(LGA), or small for gestational age(SGA). Gestational age, birth weight, length, skinfold...
Inhibitory Effects of Actinomycin-D and Pentoxifylline on the Production of IL-1α and TNF-α by Human Cord and Adult Blood Mononuclear Cells
Eun Ae Park, Kyung Hyo Kim, Gyoung Hee Kim
Clin Exp Pediatr. 1998;41(12):1700-1708.   Published online December 15, 1998
Purpose : An area of intense intrest is assessment of new therapeutic modalities that regulate the inflammatory response in acute bacterial infection is proving to be an area of interest these days. So we conducted this study to compare the inhibitory effects of actinomycin-D and pentoxifylline on the production of IL-lα and TNF-α from cord blood mononuclear cells(MC) to those...
Optimal Number of Blood Cultures and Volume of Blood Needed to Detect Bacteremia in Children
Jong Jae Kim, Cheol Am Kim, Sang Ho Baik, Eui Tak Oh, Hong Ja Kang, Kil Seo Kim
Clin Exp Pediatr. 1998;41(7):917-922.   Published online July 15, 1998
Purpose : We compared pathogen recovery rates by obtaining two blood cultures instead of one blood culture containing 1ml and collecting a larger volume, 1 to 3ml. Methods : Total of 750 blood specimens from 250 patients with fever, a temperature higher than 39℃ and suspected bacteremia were obtained. Each patient had two samples of blood, A(1ml) and B(4ml), obtained at...
Case Report
A Case of Secondary Hemosiderosis and Hepatic Fibrosis in a Pateint with Acute Myelogenous Leukemia
Hyoung No Kim, Jae Won Huh, Jae Sun Park
Clin Exp Pediatr. 1998;41(3):420-424.   Published online March 15, 1998
Chronic iron overload is associated with life-threatening complications, such as cardiomyopathy, liver cirrhosis, diabetes, hypothyroidism, hypoparathyroidism and hypogonadism. We experienced a case of secondary hemosiderosis with hepatic fibrosis in a 8-year-old boy who had been transfused 56 pints of packed red blood cells for a supportive therapy of acute myelogenous leukemia for a 27-month period. Intramuscular injection of Desferroxamine(40mg/kg/day) was...
Original Article
The Espression of Fcγ Receptors and Mac-1 in Cord and Adult Blood Monocytes and Lymphocytes and Production of Interleukin-8 by Cord and Adult Blood Mononeuclear Cells Stimulated by Lipopolysacchride
Kyung Hyo Kim, Gyoung Hee Kim
Clin Exp Pediatr. 1997;40(12):1660-1669.   Published online December 15, 1997
Purpose : The immature neonatal immune system is thought to result in increased risk of infection. Receptors for the Fcmoiety of IgG(FcγR) are important in antibodymediated clearance of microbes by monocytes/macrophages and immune regulation in lymphocytes. As an approach to understanding their role in neonatal life, we have compared the constitutive expression of the three Fc receptors-FcγRI(CD64), FcγRII(CD32) and FcγRIII(CD16)-by neonatal and adult blood monocytes...
Immunophenotypic Analysis of Umbilical Cord Blood Stem Cells
Won Ho Kang, Tai Ju Hwang, Hoon Kook, Byung Ju Kim
Clin Exp Pediatr. 1997;40(11):1572-1581.   Published online November 15, 1997
Purpose : Since umbilical cord blood (UCB), which used to be discarded, was found to be a source of enriched hematopoietic stem and progenitor cells, basic research to elucidate characteristics of UCB hematopoietic stem cells (HSCs) and its clinical application to bedside transplantation have been attempted. Moreover, stem cell transplantation (SCT) has expanded its role, not only in hematopoietic reconstitution, but in cancer therapy,...
Indomethacin-induced Changesin Renal Blood Flow and Prostaglandin E Excretion in the Cat
Yoon Suck DSuh, Dae Hun Pee, Jae Young Kim, Yu In Park, Kee Hwan Yoo, Joo Won Lee
Clin Exp Pediatr. 1997;40(9):1275-1284.   Published online September 15, 1997
Peripheral-Blood-Based PCR Assay to Identify Patients with Childhood Tuberculosis
Soo Sung Park, Byoung Moon Ahn, Eun Ryoung Kim, Il Soo Kim, Jae Jong Kim, Yu Jin Rha, Han Ho Park
Clin Exp Pediatr. 1997;40(6):841-849.   Published online June 15, 1997
Purpose : There is an urgent need for rapid and accurate diagnosis of childhood tuberculosis. Recently, developments in molecular biology have raised hopes about the possibilities of new strategies for tuberculosis diagnosis. Most of these methods have focused on the application of PCR to sputum samples from patients with suspected mycobacterial disease. We used a nested PCR to detect circuclating Mycobacterial tuberculosis DNA in...
The Expression of Fcγ Receptors in Cord and Adult Blood Granulocytes
Kyung Hyo Kim, Gyoung Hee Kim, Ju Young Seoh, Hae-Kyung Park
Clin Exp Pediatr. 1997;40(6):794-800.   Published online June 15, 1997
Purpose : The immature neonatal immune system is thought to result in increased risk of infection. Receptors for the Fc moiety of IgG(FcγR) are important in antibody-mediated clearance of microbes by granulocytes and monocytes/macrophages. As an approach to understand their role in neonatal life, we compared the constitutive expression of the three Fc receptors-FcγRI(CD64), Fcγ RII(CD32) and FcγRIII(CD16)-of neonatal granulocytes with those of adult...
Production of Interleukin-1α and Tumor Necrosis Factor-α by Human Cord and Adult Blood Mononuclear Cells Stimulated by TSST-1 and LPS
Eun Ae Park, Kyung Hyo Kim, Gyoung Hee Kim
Clin Exp Pediatr. 1997;40(5):690-700.   Published online May 15, 1997
Purpose : Immature immunological defens mechanism in the neonate may contribute to the high susceptibility to overwhelming sepsis. S. aureus TSST-1 and E. coli LPS known as one of the important pathogens of septic shock or toxic shock induce massive release of various cytokines, such as tumor necrosis factor-alpha(TNF-α) and interleukin-1α(IL-1α) produced from peripheral blood mononuclear cells(PBMC). In contrast, limited...
Whole blood and Plasma Vitamin C Concentrations of Elementary School Children in Chinju
Yoon-Ok Kim, Myoung-Bum Choi, Youn-Kyeong Cho, Sun-Kyeong Sin, Song-Ja Kim, Hyang-Ok Woo, Seoung-Hwan Kim, Hee-Shang Youn, Seon-Ju Kim, Kook-Young Maeng, Gyung-Hyuck Ko, Seung-Chul Baik, Woo-Kon Lee, Myung-Je Cho, Kwang-Ho Lee
Clin Exp Pediatr. 1997;40(3):352-360.   Published online March 15, 1997
Purpose : Recommended dietary allowance of vitamin C was determined on the basis of preventing the scurvy without considerations of the important function of the vitamin C as a first line antioxidant. So we measured the whole blood and plasma vitamin C concentrations of the contemporay healthy elementary school children in Chinju for the establishment of the optimal daily vitamin C...
The Correlation between CD34+ Cell and Nucleated RBC Counts in Human Cord Blood
Seong Man Lee, Kyu Chan Kim, Sang Woo Kim
Clin Exp Pediatr. 1996;39(10):1422-1428.   Published online October 15, 1996
Purpose : Human umbilical cord blood as a potential source of hematopoietic stem cell for stem cell transplantation in children has recently been advocated. Clinical application of cord blood transplantation, however, requires adequate blood volume and number of stem cells. Currently, the number of stem cells in the cord blood is usually measured by flowcytometry, which requires strict quality control and high costs. Here,...
A Study on Mean Blood Lead and ZPP Levels of Children around Cheonan-city,Chungcheongnam-do
Hyun Mi Kim, Hae Kyung Lee, Kyeong Bae Park, Sang Chul Park, Sang Man Shin, Kyu Dong An, Byoung Kuk Lee
Clin Exp Pediatr. 1996;39(10):1358-1363.   Published online October 15, 1996
Purpose : Recent years have witness a dramatic increase in public awareness of the health risks associated with lead exposure-particularly concerning young children. The lead poisoning in children was considered a rarity, usually resulting from unique circumstances such as in appropriate use of lead-based body cosmetics or direct administration of lead-containing folk medicine or contaminated atmosphere. The increasing concern about children with lower levels...
A Study on Blood Lead Levels of Children in Ulsan
Seung Gyu Park, In Gyeong Back, Chul Ju Jung, Dong Jin Lee, Gyeong Dong Jung
Clin Exp Pediatr. 1996;39(9):1231-1238.   Published online September 15, 1996
Purpose : Lead toxicity affects every organ system, most importantly, the central and periphral nervous systems, kidney, and blood. Not yet, there are not so many data about blood lead levels of children in Korea. The children residing in Ulsan have some risk exposured to lead because of air pollution resulted from rapid industrialization and some lead-using industries. So we estimated the blood lead...
Doppler Analysis of Postprandial Intestinal Blood Flow in Healthy Preterm Infants
Yu In Park, Young Kook Kim, Young Sook Hong
Clin Exp Pediatr. 1996;39(6):780-787.   Published online June 15, 1996
Purpose : The newborn period is a time of rapid physiological change in the gastrointestinal tract, when adaptation from a state of parenteral nutrition to the demands of enteral feeding take place. little is known about the intestinal vascular responses that accompany intestinal adaptive changes, although there is much speculation about the relationship between entreral feeding, alterations in gut perfusion,...
Serial Changes of Blood Glucose Levelsin IDDM Patients Using Intermediate-acting Insulin only Therapy
Ye Sik Kim, Mi Jung Park, Duk Hi Kim
Clin Exp Pediatr. 1996;39(4):552-557.   Published online April 15, 1996
Purpose : We investigated the clinical characteristics of IDDM patients, treated with NPH only, and evaluated current problems by measurement of serial blood glucose, insulin, C-peptide for 12 hours after administration of intermediate-acting insulin. Methods : We studied 19 IDDM patients who had been diagnosed and followed up on a regular basis at Severance hospital. They were assigned into 2 groups, one(HbA1c...
Changes of Cerebral Blood Flow Velocity before and after Closure of Ductus Arteriosus using Doppler Ultrasound in Normal Full-term Newborns
Myung Su Lee, Young Mi Hong, Kyung Hee Kim
Clin Exp Pediatr. 1995;38(12):1620-1628.   Published online December 15, 1995
Purpose : With PDA, major fluctuations of blood flow are noted between opening and closure of ductus arteriosus and there is an increase in the amplitude of each pulse of blood flow. The purpose of this study was to evaluate the changes of cerebral blood flow before and after closure of ductus arteriosus in healthy term newborns. Methods : Forty-two normal term...
Stem Cell Transplantation in Umbilical Cord Blood(I) Expansion Effects of Stem Cells in Umbilical Cord Blood with Various Hematopoietic Growth Factors
Kyung Ha Ryu, Myung Hee Chung
Clin Exp Pediatr. 1995;38(5):675-684.   Published online May 15, 1995
Stem cell transplantation is used for the patients lacking the capability of production of hem-atopoitic cells. Recently, there have been a few studies using the umbilical cord blood as a sou-rce of stem cells, however it remains unclear whether umhhilical cord blood contains sufficient amount to reconstitute the patient. Our study was designed to know that umbilical cord blood is proper...
Doppler Analysis of Renal Blood Flow in Normal Children
Hyun Joo Kwak, Jae Yong Kim, Kee Hwan Yoo, Young Sook Hong, Joo Won Lee
Clin Exp Pediatr. 1995;38(3):328-338.   Published online March 15, 1995
Purpose : Recent development in ultrasonic Doppler instrumentation have allowed the direct noninvasive assessment of human renal artery blood flow. The authors conducted this study to assess noninvasive characterization of normal renal artery blood flow variables hopping to establish standards in normal children. Methods : A total 97 normal Subjects(below the age 3 years) were examinated using by 2-D and...
The Variations of CSF Glucose-To-Blood Glucose Ratio according to the Time of Blood Sampling in Asepetic Meningitis
Dong Gui Jang, Yong Seok Choi, Mee Kyoung Lee, Chang Hee Kim, Dong Jin Lee
Clin Exp Pediatr. 1994;37(12):1687-1692.   Published online December 15, 1994
The Measurement of CSF glucose and CSF glucose-to-blood glucose ratio is a very useful laboratory test for the differential diagnosis of meningitis. We have observed the change of blood glucose & CSF glucose-to-blood glucose ratio according to the time of blood sampling in 84 patients with aseptic meningitis who had been admitted to the department of peditrics, Dong Kang hospital...
Longitudinal Change of Cerebral Blood Flow Velocity in Neonates with Perinatal Asphyxia and Hypoxic-Ischemic Encephalopathy with Doppler Technique
Kook In Park, Dong Kwan Han, Joon Soo Lee, Ran Namgung, Chul Lee
Clin Exp Pediatr. 1994;37(9):1196-1204.   Published online September 15, 1994
Fifty-three full-term, preterm, term-SGA newborn infants with perinatal asphyxia and 16 full-term infants with hypoxic-ischemic encephalopathy were studied with color Doppler songraphy to assess the postnatal change of the cerebral blood flow velocity(CBFV) longitudinally. A control group of 81 healthy infants also had CBFV recordings during the 1st week of life. Pourcelot Resistance index(PI) and area under the velocity curve(AUVC)...
A Study on Blood Lead Levels in Pediatric Inpatients
Young Ho Lee, Hyoung Shim Chang, Bong Keun Choi, Kyu Geun Hwang, Ahn Hong Choi
Clin Exp Pediatr. 1994;37(8):1111-1115.   Published online August 15, 1994
Lead is one of the most widespredad environmental toxins and its poisoning in children was considered a rarity, usually resulting from unique circumstances such as inappropriate use of lead-based body cosmetics or direct administration of lead-containing folk medicines. The increasing concern about children with lower levels of lead exposure has developed, but there are no data regarding the mean blood...
Identification of the Source of hematuria by the Ratio of the Urinary Erythrocyte MCV to That in Blood
Young Guk Kim, Gi Chan Lee, Keun Haeng Cho, Kee Hwan Yoo, Soon Kyum Kim
Clin Exp Pediatr. 1994;37(8):1097-1103.   Published online August 15, 1994
The frequent occurrence of hematuria in children necessitates diagnostic evaluation. Hematuria may occur with either renal or lower urinary tract disease. Clarification of the etiology of hematuria, whether microscopic or gross, is facilited by localizing the site of bleeding to the kidney(glomerular) or the lower urinary tract (non-glomerular). The mean cellular volume (MCV) of urinary red blood cells (RBCs) of...