Purpose : Surfactant replacement therapy significantly decreases neonatal complications and mortality in neonates with respiratory distress syndrome(RDS), but clinical responses to the treatment is not consistent. An analysis of the perinatal factors influencing the clinical response to the therapy is important for early detection of high risk and prognosis. The purpose of this study is to analyze the clinical... |
Purpose : In this study, natural pulmonary surfactant was extracted from bovine lung lavage and its surface activity was determined. To investigate the usefulness of synthetic peptides reconstituted with phospholipid as artificial surfactant, truncated peptides from surfactant protein (SP)-B were synthesized and restored the surface tension lowering activities when appropriately recombined with phospholipid. Methods : Crude natural surfactant(CNS) was isolated from lung lavage by centrifugation... |
Purpose : To examine the clinical effects of early dexamethasone treatment from postnatal age of 1 week to ventilated preterm infants with respiratory distress syndrome. Methods : 14 one-week-old ventilator-dependent infants were enrolled. Seven received dexamethasone and another 7 did not receive. The doses of dexamethasone used were 0.25mg/kg twice daily for 3 days, 0.125mg/kg twice for 1 day, then 0.125mg/kg... |
Purpose : We are inclined to analyze the relationship between the intrapulmonary right-to-left shunt and the PaO2/PaCO2 after endotracheal single-dose surfactant instillation to premature neonates with respiratory distress syndrome within 6 hours after birth. Methods : From Jan. 1993 to Jun. 1995, we have conducted a clinical trial of surfactant replacement therapy to the premature neonates with respiratory distress syndrome at the neonatal intensive care unit... |
Purpose : With the recent advent of surfactant replacement therapy, there is an increasing need for a rapid and reliable test to predict respiratory distress syndrome (RDS) immediately before or at birth. There are many investigations and methods for the detection of RDS in prenatal or postnatal period. The stable microbubble rating test (SMR-test) developed by pattle et al. is rapid and simple test... |
Foreign body aspiration(especially peanut) is the leading cause of accidental death in children under 1 year of age and most cases of serious aspiration occur between the age of 1 and 3. We report a case of severe pulmonary complication and adult respiratory distress syndrome(ARDS) secondary to peanut aspiration in 15 month old male in spite of all removal(9 pieces) by ventilating bronchoscope. Chest... |
Tracheal agenesis is the rare and uniformly lethal anomaly that presents with severe respiratory distress and aphonia after birth. In this anomaly, the trachea is usually absent and air is reaching the bronchi through a communication with the esophagus. The diagnosis should be suspected in a nowborn infant with respiratory distress whose intubation is difficult. We report an autopy case of tracheal... |
Double aortic arch is the most common type of symptomatic vascularring. In most patients, the symptoms are manifested at birth or in early infancy. Double aortic arch usually has more severe symptoms than other types of complete vascular rings. We experienced one case of complete duplicated double aortic arch with left descending aorta and left patent ductus arteriosus. A one-day-old female neonate was transferred... |
Purpose : Several kinds of exogenous pulmonary surfactants (SF), either synthetic or animalderived, are being used for the replacement therapy in respiratory distress syndrome (RDS) of newborn, especially in premature infants, and improved the neonatal mortality and morbidity. Because synthetic preparations are lack of surfactant protein (SP) and animal-derived preparations cause immunogenecity of heterogenous SP, there have been great necessity for the development of next... |
Purpose : Stable microbubble rating test(SMR) plays an important role in the clinical course and the prognosis of respiratory distress syndrome(RDS) patients, because SMR can be easily performed and it can predict quickly the neonatal RDS. After the success of the pulmonary surfactant replacement therapy in RDS infants by Fujiwara and co-workers in 1980, many supporting studies were presented and... |
Purpose : The chest radiograph is useful and reliable in assessing the severity and progres-sion of neonatal respiratory distress syndrome. To evaluate the effect of exogenous surfactant r eplacement therapy, we performed sequential observation of chest radiogratphic findings in ne-onates with respiratory distress syndrome. Methods : Two groups of infant with RDS in mechanical ventilation therapy were studied. S-urfactant(S-Tx) group(n=36) was... |
Transient tachypnea of the newborn(TTN) is a benign self-limited disease characterized by early onset and rapid recovery of tachypnea although it may occasionally have a more prolonged and protracted course. A retrospective clinical study was mad on 29 neonates with TTN admitted to NICU of Pohang St. Mary's Hospital from January 1992 to June 1993. The results were as follows: 1) TTN(36.2%) was... |
Respiratory distress syndrome (RDS) of newborn is a disease revealed high morbidity and mortality rate, especially in premature infant. To evaluate the predictive value of Stable Microbubble Rating (SMR) and Shake test on RDS in premature infant, the anthors carried out the gastric aspirates Shake test and SMR test at birth, 3 and 6 hours after birth respectively on 124 premature... |
Over a continuous 4-year period, from January 1989 till December 1992, 7,100 infants were born in Department of Obstetrics and admitted to Nursery or Neonatal Intensive Care Unit of Department of Pediatrics of Seoul National University Children's Hospital. Among them, 126 cases were diagnosed as respiratory distress syndrome (RDS) of newborn. The total incidence of RDS among all the newborns(inborn)was 1.77%.... |
Respiratory distress syndrome (RDS) of preterm infants remains a significant cause of morbidity and mortality despite improvements in neonatal intensive care and artificial ventilatory techniques. After identification of the deficiency of pulmonary surfactant is major pathophysiologic basis in RDS, artificial surfactant replacement therapy in RDS was first successfully tested by Fujiwara and co-workers in 1980. Therefore, exogenous surfactant replacement produced exellent... |
Respiratory distress syndrome (RDS) in the newborn infants remains a major cause of mortality and morbidity in the newborn period despite much improvements in neonatal intensive care and artificial ventilatory techniques. Gastric fluid was obtained from 151 patients within 6 hours after delivery. The sensitivity, specificity, and predictive value of the simple shake test (133 cases) and stable microbubble rating... |
We had previously reported the purification of bovine lung natural surfactant-phospholoipd (PNS-L) and the assessment of it's surface physical properties in vitro. To observe the clinical effectiveness of PNS-L in vivo, the degree of improvement of thoracic pressure-volume, compliance and histological changes following PNS-L instillation in premature rabbits with respiratory distress syndrome (RDS) were investigated. Rabbits, delivered prematurely by cesarean section... |
To evaluate the relationship between spontaneous diuresis and improvement of pulmonary function in respiratory distress syndrome, 15 premature neonates requiring mechanical ventilation for RDS, who admitted in NICU of Wonkwang University Hospital from January 1990 to June 1992, were studied. The results were as follows(results are mean¡¾SEM) 1) Mean birth weight of study infants was 1.82¡¾0.08Kg, and mean gestational age was 32.80¡¾0.54... |
Respiratory distress syndrome of preterm infants remains a significant cause of morbidity and mortality. Early, just after birth, prediction and recognition of RDS is so important. The precision and reliability of the stable microbuble test (SMR) and shake test as a predictor of respiratory distress syndrome were studied. A 11-=neonate who was born at Chungnam National University Hospital between November 1991... |
Surfactant replacement therapy in neonates with respiratory distress syndrome (RDS) has been introduced in our country since May 1990. The purpose of this study was to assess the effect and short-term outcome of surfactant replacement for neonatal RDS using collective data of uncontrolled trials from different hospitals in Korea. For the period May 1990 to Dec. 1991, a total of 68... |
Respiratory distress syndrome(RDS) of preterm infants remains a significant cause of morbidity and mortality despite improvements in neonatal intensive care and artificial ventiratory techniques. After identification of the deficiency of pulmonary surfactant is major pathophysiologic basis in RDS, artificial surfactant replacement therapy in RDS was first successfully tested on RDS infants by Fujiwara and co-workers in 1980. Therefore, exogenous surfactant replacement... |
Adult respiratory distress syndrome has been described as a clinical syndrome of respiratory distress and need for mechanical ventilation with positive end-expiratory pressure, diffuse pulmonary infiltration on thoracic roentgenogram, impaired pulmonary compliance, decreased lung volumes and capacities, increased alveoloarterial oxygen gradient and hyaline membrane formation. It is the clinical manifestation of injury to the terminal alveolocapillary unit as a result... |
Adult Respiratory distress Syndrome (ARDS) is a clinical entity characterized by respiratory distress and diffuse pulmonary infiltrates due to increased permeability after various kinds of insult to alveolar-capillary membrane. We experienced a case of ARDS in a 3-1/2 month old girl after Pseudomonas pneumonia, cardiac arrest and generalized convulsion. This is the report on her clincal and autopsy findings with brief review... |
Respiratory distress syndrome (RDS) in tiny infants remains a major medical challenge as they are less tolerant of supportive care. In 1959, after identification of the pulmonary surfactant (S), S replacement therapy were used to treat RDS. This idea was first successfully tested on RDS infants by Fujiwara, et. al” in 1980. Now the trial and use of S for the treatment in RDS... |
The purpose of this study was to determine the relationship between improvement of pulmonary, function and diuresis in respiratory distress syndrome. This study was based on 24 cases of RDS infants admitted in NICU of Ewha Womans University from January 1988 to December 1990. The results were as follows. 1) Mean birth weight of study cases was 2.11 kg with gestational age between 29〜39 weeks. 2) Maximum... |
Idiopathic respiratory distress syndrome (IRDS) of the newborn remains an important and signifi- cant cause of morbidity and mortality despite of improvement in neonatal care. The clinical and radiologic features observed are the results of surfactant deficiency combined with a highly compliant chest wall. We have been applied the clinical and radiologic features in the diagnosis of IRDS. In 1974, Bomsel et al reported the... |
It has been known that intrauterine thyroid hormone deficiency may be one of the factors predis- posing to RDS in premature infants. L-thyroxine has been shown to increase the production opf lung surfactant, widely accepted as deficient in RDS infants, as association between lung immaturity and fetal thyroid function is postulated. The authors investigated thyroid hormone concentration at birth and 5, 15 days of... |
Insulin seems to exert an inhibitory effect on lung maturation. The incidence of respiratory distress syndrome in neonates of diabetic mothers is significantly greater than that observed in age-and weight-matched controls. Thus hyperinsulinemia may be an important factor in the developemnt of RDS. We investigated the relationship between cord blood insulin concentration and subsequent develop- ment of RDS in 32 premature neonates born at Koryo... |
To study the predictive value of gastric aspirates shake test on respiratory distress syndrome (RDS) in the newborn infants, we carried out the shake test on gastric aspirates of all newborn who admitted to NICU of Seoul National University Hospital from July 1986 to December 1987. We successfully carried out gastric aspirates shake test on 96 newborn infants and analyzed the relation between gastric... |
We studied 51 premature babies who were admitted to the N.I.C.U. of S.N.U.H., managed with oxygen with or without artificial ventilation due to respiratory distress, and examined by indirect ophthalmoscopy between April 1, 1982 and March 31, 1986. The results were as follows; 1. Among 51 premature babies, retinopathy of prematurity developed in 12 cases (24%). 2. The high distribution of retinopathy of prematurity was observed in... |