- Review Article
- Endocrinology
- Growth plate closure and therapeutic interventions
- Ja Hyang Cho, Hae Woon Jung, Kye Shik Shim
- Clin Exp Pediatr. 2024;67(11):553-559. Published online October 28, 2024
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Height gains result from longitudinal bone growth. Upon adequate growth, growth plate closure limits longitudinal bone growth. To date, gonadotropin-releasing hormone analogs, aromatase inhibitors, C-type natriuretic peptide analogs, and fibroblast growth factor receptor 3 inhibitors have been studied or used as therapeutic interventions to delay growth plate closure and increase human height. The development of more effective therapeutic modalities for short stature, precocious puberty, and skeletal dysplasia is anticipated.
- Lifelong medical challenges and immunogenetics of Turner syndrome
- Won Kyoung Cho
- Clin Exp Pediatr. 2024;67(11):560-568. Published online July 31, 2024
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· This summary emphasizes the importance of the early diagnosis of Turner syndrome (TS) and presents a multidisciplinary approach to its prevention and management, high-lighting the need for customized care.
· Advancements in immunogenetic research may improve our understanding of TS and improve its outcomes.
· TS encompasses a wide array of medical challenges, including cardiovascular, endocrine, autoimmune, and mental health issues, as well as a heightened cancer risk.
- Neurology
- Role of nonpharmacological concussion management in children: systematic review of randomized controlled trials
- Andre Marolop Pangihutan Siahaan, Alvin Ivander, Rr. Suzy Indharty, Steven Tandean, Anastasia Grace Milenia Ginting, Masrini Ginting, Felix Khosasi, Elbert
- Clin Exp Pediatr. 2024;67(11):569-579. Published online October 28, 2024
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The long-term effects of concussion for pediatric patient remains unclear. Children and teenagers do not experience or recover from concussion in the same manner as adults do. Concussions can cause a variety of anatomical and functional alterations. Nonpharmacological approach in pediatric concussion management is an understudied field of research with significant ability to affect prognosis and quality of life. Active rehabilitation and occupational therapy were especially promising.
- Critical Care Medicine
- Recent updates on systemic treatment of atopic dermatitis
- Jiyoung Ahn
- Clin Exp Pediatr. 2024;67(11):580-588. Published online November 1, 2024
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Atopic dermatitis (AD) is a complex disease with multifactorial pathogenesis and variable clinical presentation. Up to one-fifth of patients with AD develop moderate to severe disease that is often refractory to classical therapies and can compromise quality of life. This review summarizes recent clinical evidence on biological agents and small-molecule immunotherapies for the treatment of AD.
- General Pediatrics
- Protecting our future: environmental hazards and children’s health in the face of environmental threats: a comprehensive overview
- Jungha Lee, Hyo-Bin Kim, Hun-Jong Jung, Myunghee Chung, So Eun Park, Kon-Hee Lee, Won Seop Kim, Jin-Hwa Moon, Jung Won Lee, Jae Won Shim, Sang Soo Lee, Yunkoo Kang, Young Yoo; The Environmental Health Committee of the Korean Pediatric Society
- Clin Exp Pediatr. 2024;67(11):589-598. Published online October 31, 2024
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· Exposure to air pollutants cause allergic and respiratory diseases as well as chronic kidney disease.
· Adequate physical activity and proper nutrition are essential for children to maintain good health.
· We must educate people about the harmful effects of noise, blue light, heavy metals and smoke.
· Government and society must actively decrease environ-mental hazards.
- Editorial
- Infection
- Preventing bloodstream infections in children after liver transplantation
- Young June Choe
- Clin Exp Pediatr. 2024;67(11):599-600. Published online April 18, 2024
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Liver transplantation (LT) is crucial for children with end-stage liver diseases, yet bloodstream infections (BSI) pose significant risks, despite medical advancements. Immunosuppressants, essential for preventing organ rejection, heighten infection susceptibility. Understanding BSI organisms is vital due to antimicrobial resistance. Pediatric LT recipients have unique risk factors, demanding tailored preventive measures. This systematic review on bacterial BSI emphasizes the urgency of effective prevention strategies, considering the high incidence and distinct organism profile. Further research is vital for optimizing antibiotic management and improving outcomes for this vulnerable population.
- Original Article
- Allergy
- Regional differences in diagnosis and management of cow's milk allergy
- Fabian Hendricx, Emma Robert, Jaime A. Ramirez-Mayans, Karen Rubi Ignorosa Arellano, Erick M. Toro Monjaraz, Yvan Vandenplas
- Clin Exp Pediatr. 2024;67(11):601-607. Published online October 28, 2024
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· Although there is broad consensus on many aspects regarding the symptoms, diagnosis, and treatment of cow's milk allergy, the impact of geographical, cultural, and socioeconomic factors remains unestablished.
· Availability and cost of formula for the management of cow's milk allergy have a major impact on the therapeutic choice.
· Region-specific guidelines for the treatment of cow's milk allergy are required.
- Pulmonology
- Efficacies of different treatment strategies for infants hospitalized with acute bronchiolitis
- Hyeri Jeong, Dawon Park, Eun Kyo Ha, Ju Hee Kim, Jeewon Shin, Hey-Sung Baek, Hyunsoo Hwang, Youn Ho Shin, Hye Mi Jee, Man Yong Han
- Clin Exp Pediatr. 2024;67(11):608-618. Published online October 28, 2024
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· This study analyzed 45 randomized controlled trials (5,061 participants, 13 interventions) of the comparative efficacies of treatments for acute bronchiolitis in infants.
· Inhalation therapy with epinephrine and hypertonic saline significantly reduced the length of hospital stay compared with normal saline.
· Hypertonic saline had the greatest ability to improve the clinical severity score of bronchiolitis in infants younger than 2 years of age.
- Neonatology (Perinatology)
- Mortality of very low birth weight infants by neonatal intensive care unit workload and regional group status
- Sung-Hoon Chung, Chae Young Kim, Yong-Sung Choi, Myung Hee Lee, Jae Woo Lim, Byong Sop Lee, Ki-Soo Kim; the Korean Neonatal Network
- Clin Exp Pediatr. 2024;67(11):619-627. Published online September 12, 2024
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Question: How do structural and staffing characteristics of neonatal intensive care units (NICUs) influence the mortality rates of very low birth weight infants (VLBWIs)?
Findings: NICUs with higher staffing levels, particularly with more neonatologists, and those offering advanced care levels were associated with lower mortality rates. Additionally, regional disparities were observed, with some areas demon-strating significantly higher survival rates.
Meaning: Adequate staffing and equitable regional distribution of medical resources are crucial for improving survival outcomes in VLBWIs. Efforts to enhance NICU staffing and address regional healthcare disparities are essential for optimizing care quality and reducing mortality in this vulnerable population.
- Letter to the editor
- Nephrology (Genitourinary)
- Impact of COVID-19 pandemic on healthcare provision in youth with systemic lupus erythematosus
- Punchita Apisrinitirath, Nuanpan Siripen, Pornpimol Rianthavorn
- Clin Exp Pediatr. 2024;67(11):628-631. Published online October 28, 2024
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