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"Most downloaded" Articles are from the articles published in 2024 during the last six months.
- Original Article
- Gastroenterology
- Somatic symptom severity during acute illnesses among children with functional gastrointestinal disorders
(14 times)
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Rattanachart Sirinil, Anundorn Wongteerasut
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Clin Exp Pediatr. 2025;68(8):587-593. Published online March 11, 2025
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Functional gastrointestinal disorders (FGIDs) are associated with various somatic symptoms measured using a visual analogue scale and the Children’s Somatic Symptoms Inventory-24 questionnaire. Children with FGIDs exhibited more significant somatic symptoms than controls during acute illnesses. Gastrointestinal (GI) and non-GI manifestations are significantly more common in children with FGIDs. |
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- Original Article
- Neonatology (Perinatology)
- Oral administration of bone marrow-derived mesenchymal stem cells attenuates intestinal injury in necrotizing enterocolitis
(13 times)
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Yeong Seok Lee, Yong Hoon Jun, Juyoung Lee
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Clin Exp Pediatr. 2024;67(3):152-160. Published online February 19, 2024
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Question: What is the optimal dose of bone marrow-derived mesenchymal stem cells (BM-MSCs) for treating necrotizing enterocolitis (NEC), and is orally administered BM-MSC effective?
Findings: High (1×106 cells) or multiple BM-MSC doses showed similar effects as low (1×105 cells) doses of intraperitoneally administered BM-MSCs. Furthermore, orally administered BM-MSCs were as effective as intraperitoneally administered BM-MSCs.
Meaning: Orally administered low-dose BM-MSCs are a potential treatment for NEC. |
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- Editorial
- Nephrology (Genitourinary)
- Clinical considerations and practical issues of kidney complications in children after COVID-19 infection or vaccination
(13 times)
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Jiwon Jung, Joo Hoon Lee
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Clin Exp Pediatr. 2024;67(1):35-36. Published online November 17, 2023
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· The proper monitoring for and treatment of coronavirus disease 2019 (COVID-19)-induced acute kidney injury, which is common in critically ill children, are recommended.
· Glomerulopathy associated with COVID-19 or its vaccination has been reported, and the overall clinical course is similar to that of non-COVID-19-associated diseases.
· Additional COVID-19 vaccinations are recommended; however, careful and individualized decisions should be made in patients with COVID-19- or vaccination-associated glomerulopathy. |
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- Allergy
- Advancements in food allergen immunotherapy: improving quality of life and reducing risks
(13 times)
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Jihyun Kim
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Clin Exp Pediatr. 2024;67(12):672-674. Published online July 31, 2024
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· Pediatric food allergies considerably impair patient and family quality of life, particularly those with persistent allergies to common food allergens.
· Recent research has focused on developing diverse approaches to food allergen immunotherapy, showing promising outcomes of oral, sublingual, and epicutaneous immuno therapies.
· Critical considerations in immunotherapy candidate selection underscore the need for personalized approaches and reliable biomarkers in future studies to improve treatment outcomes. |
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- Original Article
- Neurology
- Changes in frequency of benign convulsions with mild gastroenteritis and their viral causes before and during the COVID-19 pandemic: a single-center study
(12 times)
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Hyejin Na, Sanghoon Lee, Seo Hee Kim, Young Ok Kim
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Clin Exp Pediatr. 2024;67(4):213-220. Published online March 19, 2024
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Question: Did coronavirus disease 2019 (COVID-19) affect the frequency, seasonal variation, or virus type of benign convulsions with mild gastroenteritis (CwG)?
Findings: We compared 41 cases of CwG before and during the COVID-19 pandemic. After March 2020, frequency did not change significantly (18 patients vs. 23 patients), seasonal variation was lost, and number of cases of enteric adenovirus-associated CwG increased (1 cases vs. 7 cases).
Meaning: The COVID-19 pandemic affected CwG. |
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- Original Article
- Neonatology (Perinatology)
- Mortality of very low birth weight infants by neonatal intensive care unit workload and regional group status
(12 times)
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Sung-Hoon Chung, Chae Young Kim, Yong-Sung Choi, Myung Hee Lee, Jae Woo Lim, Byong Sop Lee, Ki-Soo Kim; the Korean Neonatal Network
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Clin Exp Pediatr. 2024;67(11):619-627. Published online September 12, 2024
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Question: How do structural and staffing characteristics of neonatal intensive care units (NICUs) influence the mortality rates of very low birth weight infants (VLBWIs)?
Findings: NICUs with higher staffing levels, particularly with more neonatologists, and those offering advanced care levels were associated with lower mortality rates. Additionally, regional disparities were observed, with some areas demon-strating significantly higher survival rates.
Meaning: Adequate staffing and equitable regional distribution of medical resources are crucial for improving survival outcomes in VLBWIs. Efforts to enhance NICU staffing and address regional healthcare disparities are essential for optimizing care quality and reducing mortality in this vulnerable population. |
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- Oncology
- Prognostic role of mid-regional pro-adrenomedullin in predicting infection in pediatric cancer with febrile neutropenia
(12 times)
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Seham M. Ragab, Sara Mahmoud El-Deeb, Ahmed Saeed, Asmaa A. Mahmoud
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Clin Exp Pediatr. 2025;68(6):445-453. Published online January 13, 2025
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· Infection remains a leading cause of death in febrile neutropenia (FN).
· Mid-regional pro-adrenomedullin (MR-ProADM) levels are higher among patients with FN and a bacterial infection.
· A longer FN duration and hospital stay length as well as elevated C-reactive protein, procalcitonin, and MR-ProADM levels are significant risk factors for mortality. |
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- Gastroenterology
- Efficacy and safety of carbon dioxide versus room-air insufflation in pediatric colonoscopy: a randomized controlled trial
(12 times)
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Ajay Aravind, Ujjal Poddar, Anshu Srivastava, Moinak Sen Sarma
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Clin Exp Pediatr. 2025;68(8):594-600. Published online March 11, 2025
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CO2 insufflation has been used instead of air insufflation to reduce postprocedure pain and discomfort in adults; however, adequately powered studies in children are scarce. This randomized controlled trial of 200 children showed that CO2 insufflation reduces postprocedure pain and discomfort during pediatric colonoscopy with no signs of CO2 retention. CO2 insufflation is safe and causes less pain in children. |
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- Editorial
- Neonatology (Perinatology)
- Impacts of maternal COVID-19 during pregnancy on neonatal health and epidemiology
(11 times)
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Jae Woo Lim
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Clin Exp Pediatr. 2024;67(3):149-151. Published online December 28, 2023
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Newborns born to mothers infected with coronavirus disease 2019 (COVID-19) should be closely monitored for respiratory disorders, such as transient tachypnea of the newborn, regardless of their COVID-19 test results. Further research is required of the development of infants born to mothers with COVID-19. The trends in Korea's birth rate and infant mortality rates have not been significantly affected by COVID-19. |
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- Exploring the role of laryngeal masks in neonatal resuscitation
(10 times)
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Euiseok Jung
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Clin Exp Pediatr. 2024;67(5):247-248. Published online December 28, 2023
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· Laryngeal masks (LMs) offer stable airway access and skill retention advantages, making them promising alternatives to positive-pressure ventilation in neonatal care.
· The ease of teaching LM insertion techniques to less experienced providers addresses the need for swift intervention and skill retention.
· Careful consideration of the benefits and challenges of LMs is essential in determining their effective integration into enhanced neonatal resuscitation protocols. |
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- Critical Care Medicine
- Is it possible to provide palliative care to pediatric patients with neurological diseases?
(10 times)
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Young-Hoon Kim
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Clin Exp Pediatr. 2024;67(8):403-404. Published online February 15, 2024
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· Patients with neurological diseases often require external mechanical support to maintain mechanical ventilation or supply.
· Little has been done to help the families of affected children make difficult decisions that carry significant physical and psychological consequences.
· The establishment of a department that provides pediatric palliative care for neurological patients should be considered. |
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- Original Article
- Endocrinology
- Prednisolone impairs trabecular bone score changes in adolescents with 21-hydroxylase deficiency
(10 times)
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Pattara Wiromrat, Yutapong Raruenrom, Phanpaphorn Namphaisan, Nantaporn Wongsurawat, Ouyporn Panamonta, Chatlert Pongchaiyakul
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Clin Exp Pediatr. 2025;68(3):238-246. Published online November 13, 2024
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Question: What is the prevalence of an impaired trabecular bone score (TBS), a measure of bone microarchitecture, in adolescents with 21-hydroxylase deficiency (21OHD)? Do prednisolone and hydrocortisone affect TBS differently in this patient population?
Finding: Impaired TBS was observed in 18% of participants. Prednisolone use negatively impacted TBS change.
Meaning: Impaired TBS is prevalent among adolescents with 21OHD. Prednisolone impairs trabecular bone microarchitecture development. |
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- Infection
- Role of miRNA-146a and miRNA-125b in Helicobacter pylori
(10 times)
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Nashwa Farouk Mohamed, Ola G.A. Behairy, Manal S. EL-Defrawy, Mona Mahmoud Elsayed, Naglaa F. Alhusseini
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Clin Exp Pediatr. 2025;68(10):781-789. Published online April 1, 2025
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Question: Why is the early detection of Helicobacter pylori-associated gastritis in children important?
Finding: The early detection of H. pylori-related gastritis is crucial for its effective management, especially in pediatric patients with dyspepsia.
Meaning: The use of miRNA signatures could detect early gastritis, enabling timely H. pylori eradication treatment to mitigate growth delays and cancer risk. |
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- Editorial
- Allergy
- Trends in food allergen immunotherapy in Korea after changed national regulations
(9 times)
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Tae Won Song
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Clin Exp Pediatr. 2024;67(4):201-202. Published online November 21, 2023
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National regulations, academic guidelines, and clinical trends in food allergen immunotherapies (FA-AIT) differ among countries and have changed rapidly. Current officially approved FA-AIT are oral immunotherapy (OIT) using heated milk/egg in Korea and peanut OIT using standardized products in the United States and Europe. FA-AIT should be administered by specialist physicians with experience administering oral food challenge tests and managing severe allergic reactions inside and outside research settings. |
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- Erratum: Authour correciton
- Author correction: Bifidobacterium animalis subsp. lactis BLa80 for preventing allergic, respiratory, and gastrointestinal diseases in young children in China: a randomized double-blind placebo-controlled trial
(9 times)
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Ke Chen, Xi Zhang, Kaihong Zeng, Jiayi Zhong, Shanshan Jin, Yang Nie, Ping Yang, Nianyang He, Haixia Chen, Yanmei Cao, Yunrong Fu, Ziji Fang, Wei Jiang, Changqi Lium
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Clin Exp Pediatr. 2026;69(5):455-455. Published online April 28, 2026
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- Editorial
- Infection
- Preventing bloodstream infections in children after liver transplantation
(8 times)
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Young June Choe
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Clin Exp Pediatr. 2024;67(11):599-600. Published online April 18, 2024
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Liver transplantation (LT) is crucial for children with end-stage liver diseases, yet bloodstream infections (BSI) pose significant risks, despite medical advancements. Immunosuppressants, essential for preventing organ rejection, heighten infection susceptibility. Understanding BSI organisms is vital due to antimicrobial resistance. Pediatric LT recipients have unique risk factors, demanding tailored preventive measures. This systematic review on bacterial BSI emphasizes the urgency of effective prevention strategies, considering the high incidence and distinct organism profile. Further research is vital for optimizing antibiotic management and improving outcomes for this vulnerable population. |
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- Original Article
- Cardiology
- Comparative analysis of adolescent hypertension definitions for predicting early adulthood carotid artery intima-media thickness: Tehran lipid and glucose study
(8 times)
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Maryam Barzin, Shirin Yaghoobpoor, Maryam Mahdavi, Behnaz Abiri, Majid Valizadeh, Fereidoun Azizi, Pooneh Dehghan, Farhad Hosseinpanah
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Clin Exp Pediatr. 2024;67(12):694-703. Published online September 12, 2024
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Question: What is the prevalence of HTN among adolescents enrolled in the TLGS according to 3 different accepted definitions (4th report, ESH, and AAP-CPG). Also, what is the ability of each of these definitions in predicting early adulthood CIMT, as a surrogate for cardiovascular disease events?
Finding: The highest and lowest prevalence of stage 1 HTN was observed with the AAP-CPG (17.7%) and ESH (8.8%), respectively. Similarly, the highest and lowest prevalence of stage 2 HTN was noted with the AAP-CPG (1.5%) and ESH (0.8%), respectively. The highest to lowest predictive abilities belonged to the 4th report, ESH, and AAP-CPG, respectively.
Meaning: Among the various definitions of pediatric HTN, the 4th report offered the best ability to predict a high CIMT during early adulthood, followed by the ESH and AAP-CPG. |
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- Developmental and Behavioral Medicine
- Effectiveness of online responsive teaching in young children with developmental disabilities: a pilot study
(7 times)
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Jung Sook Yeom, Jeongmee Kim
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Clin Exp Pediatr. 2024;67(6):303-311. Published online May 21, 2024
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Question: Does online responsive teaching (RT) impact children's and parents’ emotions and behaviors, and do parents find it satisfactory?
Finding: Online RT significantly improved children's pivotal and problem behaviors, decreased parenting stress, and enhanced parental interactive styles with high satisfaction.
Meaning: This pilot study's findings suggest that online RT can enhance child outcomes, offering accessible interventions amid challenges such as limited access and pandemics. |
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- Clinical Note
- Neurology
- Expanding association between BICD2 variants and brain malformations and associated lissencephaly
(7 times)
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Jaeso Cho, Haeryung Kim, Seoungbok Lee, Jihoon G Yoon, HyeJin Kim, Minhye Kim, Seoyun Jang, Woojoong Kim, Soo Yeon Kim, Jong Hee Chae
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Clin Exp Pediatr. 2024;67(1):54-56. Published online December 21, 2023
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- Editorial
- Allergy
- Effect of metabolic syndrome on pulmonary dysfunction in children with asthma
(7 times)
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Hyo-Bin Kim
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Clin Exp Pediatr. 2025;68(2):136-137. Published online November 13, 2024
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· The prevalence of metabolic syndrome increased in Korean children during the coronavirus disease 2019 pandemic owing to reduced physical activity resulting from social distancing.
· Metabolic syndrome impacts pulmonary dysfunction in childhood asthma.
· Further studies are needed to understand the mechanism linking asthma and metabolic syndrome and develop interventions. |
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- Review Article
- Other
- Children’s health affected by parent’s behavioral characteristics: a review
(6 times)
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Sung Eun Kim, Jongin Lee
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Clin Exp Pediatr. 2024;67(5):232-239. Published online August 21, 2023
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· Parents’ occupational hazards, long working hours, and smoking behaviors should be modified adequately to minimize adverse health effects on their children.
· As of 2023, several diseases from fetal exposure to occupational hazards can be compensated with Industrial Accident Compensation Insurance in South Korea.
· A directed acyclic graph is recommended for medical research to control the effects of parents’ behaviors on children’s health. |
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- Editorial
- Neurobehavior
- Importance of pediatrician’s role in preventing positional plagiocephaly
(6 times)
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Hee-Jeong Kang
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Clin Exp Pediatr. 2024;67(6):294-295. Published online May 21, 2024
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· Plagiocephaly is characterized by the asymmetrical shape of a baby’s head.
· Since positional plagiocephaly is associated with developmental delay and further musculoskeletal problems, early detection allows for timely intervention and prevents worsening of the condition.
· Pediatricians can educate parents about proper head positioning and encourage supervised tummy time during awake hours. |
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