Most downloaded
- Page Path
-
- HOME
- BROWSE ARTICLES
- Most downloaded
"Most downloaded" Articles are from the articles published in 2023 during the last six months.
- Review Article
- Neurology
- Gut microbiota affects brain development and behavior
(41 times)
-
Gun-Ha Kim, Jung-Ok Shim
-
Clin Exp Pediatr. 2023;66(7):274-280. Published online November 8, 2022
-
|
· The gut microbiota can alter a host’s brain development and behavior.
· Gut bacteria communicate with the brain via the microbiota-gut-brain axis.
· Fecal microbial transplantation is a promising treatment strategy for autism spectrum disorder. |
-
-
- Editorial
- Neonatology (Perinatology)
- Advancements and challenges in neonatal resuscitation: embracing laryngeal mask airways for improved outcomes
(41 times)
-
Jang Hoon Lee
-
Clin Exp Pediatr. 2025;68(4):298-299. Published online November 28, 2024
-
|
|
Positive pressure ventilation (PPV) is the most critical intervention provided during delivery room resuscitation. In the new guidelines, this recommendation has been expanded to suggest the use of laryngeal mask airyway (LMA) versus face masks for PPV. Evidence-based information and hands-on training related to this practice will help more healthcare providers become familiar with and appropriately use LMA during delivery room resuscitations. |
-
-
- Original Article
- Nutrition
- Energy drink consumption among Korean adolescents: prevalence and associated factors
(40 times)
-
Jee-Seon Shim, Jeong Mi Lee
-
Clin Exp Pediatr. 2024;67(10):531-539. Published online September 24, 2024
-
|
Question: How prevalent is energy drink consumption among Korean adolescents and what are the associated factors?
Findings: The prevalence of energy drink consumption among Korean adolescents increased from 3.2% in 2014 to 12.2% in 2019. Energy drink consumption varies according to sociode-mographic and individual factors.
Meaning: Policies and educational strategies are needed to reduce energy drink consumption in adolescents. |
-
-
- Infection
- Clinical characteristics and associated factors of pediatric acute necrotizing encephalopathy: a retrospective study
(40 times)
-
Huiling Zhang, Yilong Wang, Qianyun Ding, Xuekun Li, Sheng Ye
-
Clin Exp Pediatr. 2025;68(2):153-162. Published online November 11, 2024
-
|
· The mortality rate of acute necrotizing encephalopathy was high.
· Laboratory tests revealed that the fatal group had higher creatinine, lactate, activated partial thromboplastin time, thrombin time, interleukin (IL)-6, IL-10, creatine kinase, and D-dimer than survivors.
· The fatal group displayed lower Glasgow Coma Scale scores and arterial pH. |
-
-
- Editorial
- General Pediatrics
- Artificial intelligence in pediatric healthcare: bridging potential, clinical practice, and ethical considerations
(40 times)
-
Yoon Lee, Seohyun Hong, Dong Keon Yon
-
Clin Exp Pediatr. 2025;68(9):652-655. Published online August 28, 2025
-
|
· Artificial intelligence (AI) holds transformative potential for pediatric healthcare, with applications spanning prevention, diagnosis, treatment, and follow-up across diverse subspecialties; however, ethical concerns, scarcity of pediatric- specific data, and limited funding remain significant challenges.
· International consensus on pediatric AI guidelines, expanding child-specific datasets, and incorporating explainable AI are essential to ensure safety and trust.
· Multicenter collaboration and increased investment can address these gaps, enabling equitable, reliable, and pediatric- centered AI solutions. |
-
-
- Review Article
- General Pediatrics
- Protecting our future: environmental hazards and children’s health in the face of environmental threats: a comprehensive overview
(39 times)
-
Jungha Lee, Hyo-Bin Kim, Hun-Jong Jung, Myunghee Chung, So Eun Park, Kon-Hee Lee, Won Seop Kim, Jin-Hwa Moon, Jung Won Lee, Jae Won Shim, Sang Soo Lee, Yunkoo Kang, Young Yoo; The Environmental Health Committee of the Korean Pediatric Society
-
Clin Exp Pediatr. 2024;67(11):589-598. Published online October 31, 2024
-
|
· Exposure to air pollutants cause allergic and respiratory diseases as well as chronic kidney disease.
· Adequate physical activity and proper nutrition are essential for children to maintain good health.
· We must educate people about the harmful effects of noise, blue light, heavy metals and smoke.
· Government and society must actively decrease environ-mental hazards. |
-
-
- Nephrology (Genitourinary)
- Effects of diethylene glycol contamination of pharmaceutical products on unexplained acute kidney injury in children: a systematic review
(38 times)
-
Sani Rachman Soleman, Muhammad Luthfi Adnan, Hilmi Ardian Sudiarto, Satria Bintang Mahathma, Alya Ayu Tazkia, Hana Afifah Firdaus, Alfreda Amelia Khotijah, Miranti Dewi Pramaningtyas, Emi Azmi Choironi
-
Clin Exp Pediatr. 2024;67(8):395-402. Published online January 4, 2024
-
|
A recent unexplained acute kidney injury (AKI) outbreak due to pharmaceutical product contamination with diethylene glycol (DEG) raises public attention. Our study revealed that DEG-contaminated paracetamol causes unexplained AKI in children. However, paracetamol is not the only contaminated drug. Other drugs, such as cough expectorants, antihistamines, and sedatives, can also be affected. Other chemicals, such as ethylene glycol and propylene glycol, can also contribute to poisonings. |
-
-
- Original Article
- Other
- Virtual, augmented, and mixed reality: potential clinical and training applications in pediatrics
(38 times)
-
Suyoung Yoo, Meong Hi Son
-
Clin Exp Pediatr. 2024;67(2):92-103. Published online May 24, 2023
-
|
· Review of articles that investigated the applications of virtual, augmented, or mixed reality in pediatric clinical settings and in the training of pediatric medical professionals was conducted.
· A total of 89 studies were retrieved, with 36 randomized controlled trials.
· In most studies, intervention using the novel technology was at least as effective or more effective than the traditional method.
· Use of virtual, augmented, and mixed reality has potential in pediatrics. |
-
-
- Genetics and Metabolism
- Role of microRNA-498 and microRNA-410 in neonatal hypoxic-ischemic encephalopathy
(38 times)
-
Eman Salah Eldeen Arafat, Hasnaa Hesham Abotaleb, Dina Abdel Razek Midan, Abdel Hamid Abdo Ismail, Zeinab Sabri Abouzouna
-
Clin Exp Pediatr. 2025;68(7):512-521. Published online February 26, 2025
-
|
Question: Is it role of microRNA-410 (miRNA-410) and microRNA-498 (miRNA-498) in neonatal hypoxic-ischemic encephalopathy (HIE)?
Findings: miRNA-498 and miRNA-410 can be auxiliary diagnostic and prognostic tools for neonatal HIE.
Meaning: we can use miRNA-498 and miRNA-410 as markers and indicator for HIE. |
-
-
- Review Article
- Other
- Use of virtual reality in children in a broad range of medical settings: a systematic narrative review of recent meta-analyses
(37 times)
-
Emily Antonovics, Grammatina Boitsios, Thomas Saliba
-
Clin Exp Pediatr. 2024;67(6):274-282. Published online May 21, 2024
-
|
· Virtual reality (VR) is becoming increasingly common for entertainment and in medical settings.
· VR is useful for treating children with cerebral palsy.
· VR can help with attention deficit/hyperactivity disorder symptoms.
· VR can decrease pain perception in children undergoing burn wound care.
· VR can reduce preoperative anxiety.
· VR can reduce fear and pain during needle-involving procedures. |
-
-
- Neurology
- Role of nonpharmacological concussion management in children: systematic review of randomized controlled trials
(37 times)
-
Andre Marolop Pangihutan Siahaan, Alvin Ivander, Rr. Suzy Indharty, Steven Tandean, Anastasia Grace Milenia Ginting, Masrini Ginting, Felix Khosasi, Elbert
-
Clin Exp Pediatr. 2024;67(11):569-579. Published online October 28, 2024
-
|
The long-term effects of concussion for pediatric patient remains unclear. Children and teenagers do not experience or recover from concussion in the same manner as adults do. Concussions can cause a variety of anatomical and functional alterations. Nonpharmacological approach in pediatric concussion management is an understudied field of research with significant ability to affect prognosis and quality of life. Active rehabilitation and occupational therapy were especially promising. |
-
-
- Allergy
- Practical issues of oral immunotherapy for egg or milk allergy
(36 times)
-
Sukyung Kim, Kangmo Ahn, Jihyun Kim
-
Clin Exp Pediatr. 2024;67(3):140-148. Published online June 19, 2023
-
|
· Oral immunotherapy should be supervised by pediatricians with experience administering oral food challenge tests and managing allergic reactions.
· Food allergen intake is gradually increased and maintained for years.
· Patients may experience allergic reactions and psychological problems.
· Adjunctive therapies (biologics, antihistamines, and leukotriene receptor antagonists) may improve efficacy and safety.
· Contraindications include uncontrolled asthma, malignancy, active autoimmune disorders, and beta-blocker usage. |
-
-
- Original Article
- Infection
- Construction and validation of predictive models for intravenous immunoglobulin–resistant Kawasaki disease using an interpretable machine learning approach
(36 times)
-
Linfan Deng, Jian Zhao, Ting Wang, Bin Liu, Jun Jiang, Peng Jia, Dong Liu, Gang Li
-
Clin Exp Pediatr. 2024;67(8):405-414. Published online July 23, 2024
-
|
Question: Is there a reliable model to predict intravenous immunoglobulin (IVIG)-resistant Kawasaki disease (KD)?
Finding: We constructed 5 machine learning models to predict IVIG-resistant KD. Extreme gradient boosting (XGBoost) model was superior to logistic, support vector machine, light gradient boosting machine and multiple layers perception models. The SHAP (SHapley Additive exPlanations) value interpreted the contribution of each feature in XGBoost model.
Meaning: XGBoost model showed the excellent performance to predict IVIG-resistant KD with explainable and visualizable machine learning algorithm. |
-
-
- Review Article
- Critical Care Medicine
- Recent updates on systemic treatment of atopic dermatitis
(36 times)
-
Jiyoung Ahn
-
Clin Exp Pediatr. 2024;67(11):580-588. Published online November 1, 2024
-
|
|
Atopic dermatitis (AD) is a complex disease with multifactorial pathogenesis and variable clinical presentation. Up to one-fifth of patients with AD develop moderate to severe disease that is often refractory to classical therapies and can compromise quality of life. This review summarizes recent clinical evidence on biological agents and small-molecule immunotherapies for the treatment of AD. |
-
-
- Original Article
- Neonatology (Perinatology)
- Mortality of very low birth weight infants by neonatal intensive care unit workload and regional group status
(36 times)
-
Sung-Hoon Chung, Chae Young Kim, Yong-Sung Choi, Myung Hee Lee, Jae Woo Lim, Byong Sop Lee, Ki-Soo Kim; the Korean Neonatal Network
-
Clin Exp Pediatr. 2024;67(11):619-627. Published online September 12, 2024
-
|
Question: How do structural and staffing characteristics of neonatal intensive care units (NICUs) influence the mortality rates of very low birth weight infants (VLBWIs)?
Findings: NICUs with higher staffing levels, particularly with more neonatologists, and those offering advanced care levels were associated with lower mortality rates. Additionally, regional disparities were observed, with some areas demon-strating significantly higher survival rates.
Meaning: Adequate staffing and equitable regional distribution of medical resources are crucial for improving survival outcomes in VLBWIs. Efforts to enhance NICU staffing and address regional healthcare disparities are essential for optimizing care quality and reducing mortality in this vulnerable population. |
-
-
- Gastroenterology
- Differences in immune cells and gene expression in human milk by parity on integrated scRNA sequencing
(36 times)
-
Dae Yong Yi, Hong-Jai Park, Min Sun Shin, Hyoungsu Kim, Sang Jin Lee, Insoo Kang
-
Clin Exp Pediatr. 2025;68(2):141-152. Published online January 10, 2025
-
|
Question: Is there a difference in immune cells in human breast milk by parity?
Finding: There were higher proportions of monocytes and T/B cells in the primiparous and multiparous group, respectively. The expression of genes with a direct role in the infant immune system and immune response-related genes were highest in the primiparous group
Meaning: There were parity-dependent differences in the expression of genes between innate and adaptive immune cells. |
-
-
- Review Article
- Endocrinology
- Hidden link between endocrine-disrupting chemicals and pediatric obesity
(36 times)
-
Min Won Shin, Shin-Hye Kim
-
Clin Exp Pediatr. 2025;68(3):199-222. Published online November 28, 2024
-
|
Studies indicate potential connections between exposure to endocrine-disrupting chemicals (EDCs) and childhood obesity. Variations in the impact of EDCs in epidemiological studies may result from differences in exposure concentrations and timing, measurement methods, and interactive effects of multiple EDCs. Longitudinal studies on exposure to multiple EDCs are crucial to elucidating their contribution to pediatric obesity and minimize the adverse health consequences of EDC exposure. |
-
-
- Editorial
- Other
- Beyond the eye: a multidisciplinary perspective on managing pediatric myopia
(36 times)
-
Eoi Jong Seo
-
Clin Exp Pediatr. 2025;68(8):566-568. Published online July 18, 2025
-
|
Myopia is a growing global public health concern because of its association with irreversible vision loss such as myopic traction maculopathy, rhegmatogenous retinal detachment, and glaucoma. The effective prevention of myopia in childhood requires a multidisciplinary approach that integrates ophthalmologic care with lifestyle, nutrition, and sleep interventions. Early detection through regular visual screening in schools and primary care settings and timely ophthalmology referrals are critical to preventing high myopia. |
-
-
- Neonatology (Perinatology)
- Efficacy of body position on gastric residual in preterm infant: a systematic review and meta-analysis
(34 times)
-
Kurvatteppa Halemani, Alwin Issac, Sanjay Dhiraaj, Prabhaker Mishra
-
Clin Exp Pediatr. 2023;66(6):262-270. Published online November 30, 2022
-
|
Breastfeeding and it's tolerance are the positive indicators for preterm babies. Placing the preterm infant in the right lateral or prone position after feed had lesser gastric residual volume compared to placing them in left lateral or supine positions. The post-feed position is a vital element in enhancing feeding tolerance, mechanical functions of the gastrointestinal tract and the overall development of preterm infants. |
-
-
- General Pediatrics
- Role of proper postnatal care in continued exclusive breastfeeding among young Indonesian mothers
(34 times)
-
Wahyu Triadmajani, Shinta Prawitasari, Abdul Wahab
-
Clin Exp Pediatr. 2024;67(12):686-693. Published online September 12, 2024
-
|
Question: Is proper postnatal care (PNC) associated with exclusive breastfeeding (EBF) practice among young Indonesian mothers?
Finding: Proper PNC elevates the likelihood of EBF among Indonesian adolescent mothers aged 15–19 years.
Meaning: Breastfeeding services should be provided during the early postnatal period to support EBF practice among adolescent mothers. High-quality PNC is a tailored intervention for vulnerable populations. |
-
-
- Review Article
- Neonatology (Perinatology)
- Influence of infant microbiome on health and development
(33 times)
-
Noelle Younge
-
Clin Exp Pediatr. 2024;67(5):224-231. Published online August 21, 2023
-
|
· The infant gut microbiome is highly dynamic and individualized.
· Microbes are vertically transmitted from mother to infant during delivery and throughout infancy.
· Delivery mode, gestational age, diet, and antibiotic use influence infant microbiome composition and function.
· In animal studies, the microbiome played critical roles in the structural and functional development of the infant gastrointestinal and immune systems.
· Microbiome-targeted therapies have great potential to reduce infant morbidity and mortality. |
-
-
- General Pediatrics
- Metabolic complications of obesity in children and adolescents
(33 times)
-
Hyunjin Park, Jung Eun Choi, Seunghee Jun, Hyelim Lee, Hae Soon Kim, Hye Ah Lee, Hyesook Park
-
Clin Exp Pediatr. 2024;67(7):347-355. Published online November 16, 2023
-
|
· Pediatric obesity increases the risk of metabolic complications (insulin resistance, dyslipidemia, nonalcoholic fatty liver disease) and long-term cardiovascular diseases.
· A new obesity definition and various indicators (continuous metabolic syndrome score, pediatric simple metabolic syndrome score, fatty liver index) have been proposed to evaluate children’s susceptibility to metabolic disorders.
· Laboratory and body composition tests in pediatric screenings can identify groups at high risk of metabolic complications of obesity. |
-
-
- Allergy
- Moderate to severe atopic dermatitis in children: focus on systemic Th2 cytokine receptor antagonists and Janus kinase inhibitors
(33 times)
-
Jeong Hee Kim, Mona Salem Samra
-
Clin Exp Pediatr. 2024;67(2):64-79. Published online June 14, 2023
-
|
· Atopic dermatitis (AD) is characterized by a strong T helper (Th)2 response, although the extents of Th22, Th17/ interleukin (IL)-23, and Th1 responses vary among disease subtypes.
· Children with moderate to severe AD may require early systemic therapy to reduce the systemic inflammation caused by increased Th2 cytokine levels.
· Dupilumab, which blocks IL-4/IL-13 receptor, has equivalent efficacy for extrinsic and intrinsic AD and a favorable safety profile in infants and children aged 6 months and older. |
-
-
- Original Article
- Neurology
- Evaluation of pediatric migraine triggers: a single-center study
(33 times)
-
Hey-Joon Son, Joo-Ok Jin, Kon-Hee Lee
-
Clin Exp Pediatr. 2025;68(2):163-169. Published online November 11, 2024
-
|
Question: What are the primary triggers for pediatric migraines, and how do they impact clinical management?
Finding: Common triggers for pediatric migraines include sleep disturbances, academic stress, and motion sickness, with academic stress identified as the most intense.
Meaning: Recognizing and addressing specific triggers like sleep disturbance and academic stress is crucial to effectively managing pediatric migraines with emphasis on personalized care to improve outcomes. |
-
-
- Original Article
- Infection
- Seroprevalence of maternal peripartum human T-cell lymphotropic virus type-1 infection: a systematic review and meta-analysis of the Nigerian literature
(32 times)
-
Abdulrasheed Usman, Muhammad Hamis Musa, Bukhari Isah Shuaib, Olayemi Balogun, Mukhtar Adeiza
-
Clin Exp Pediatr. 2023;66(7):307-316. Published online December 22, 2022
-
|
The peripartum period is an important transmission time for human T-cell lymphotropic virus-1 (HTLV-1) infection, mainly via breastfeeding and partly through the placental tissues of carrier mothers. Although most HTLV-1–infected individuals are asymptomatic, fetal and childhood infections often result in several diseases with disappointing treatment outcomes. An estimated HTLV-1 burden in Nigeria among perinatal women must be determined to enable rational planning of a comprehensive health care intervention. |
-
-
